Table 4

HR and 95% CI adjusted for sex, residential area, year of diagnosis age and educational level

Calendar period of RA diagnosisRA duration categories HR (95% CI)p Value for heterogeneity in HRs by disease duration*
Total follow-up<1 year1-<5 years5–10 years>10 years
Total study period1.41 (1.29 to 1.54)1.12 (0.88 to 1.43)1.43 (1.26 to 1.63)1.57 (1.34 to 1.83)1.30 (1.01 to 1.68)0.13
1997–20021.41 (1.24 to 1.60)1.14 (0.73 to 1.78)1.42 (1.15 to 1.76)1.60 (1.29 to 1.97)1.26 (0.96 to 1.65)0.42
2003–20061.47 (1.24 to 1.74)1.18 (0.71 to 1.97)1.47 (1.14 to 1.90)1.59 (1.22 to 2.07)1.77 (0.75 to 4.18)0.76
2007–20101.38 (1.13 to 1.68)1.20 (0.76 to 1.90)1.38 (1.07 to 1.76)1.56 (0.95 to 2.54). (.-.)0.60
2011–20141.19 (0.85 to 1.67)0.96 (0.57 to 1.6)1.48 (0.94 to 2.32). (.-.). (.-.)0.47
p Value for heterogeneity in HRs by calendar period*0.670.800.910.940.81
  • Overall and stratified by calendar period of RA diagnosis and time since RA diagnosis.

  • *Wald χ2 tests of heterogeneity with 2–3 df, depending on the number of variables tested.

  • RA, rheumatoid arthritis.