TableĀ 1

Associations between the occurrence of anti-CII and anti-CCP, individually or in combination and clinical symptoms during 5-year follow-up after RA diagnosis

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  • Median levels are shown for anti-CII/anti-CCP double-negative patients (n=285), anti-CII-positive and anti-CCP-negative patients (n=20), anti-CII-negative and anti-CCP-positive patients (n=432) and anti-CII-positive and anti-CCP2-positive patients (n=36). p Values refer to comparisons with the anti-CII-negative/anti-CCP2 double-negative group. Significant differences are depicted in bold, and also underlined if the median level for the corresponding antibody is lower than for the double-negative group.

  • Corresponding data for tender joint count, DAS28CRP, pain-VAS, global-VAS and Health Assessment Questionnaire are shown in online supplementary table S2.

  • CII, collagen type II; CRP, C reactive protein; DAS28, Disease Activity Score encompassing 28 joints based on ESR; ESR, erythrocyte sedimentation rate; mo, months; RA, rheumatoid arthritis; SJC, swollen joint count; VAS, Visual Analogue Scale.