Table 4

Case–control association between children carrying one or two risk alleles and allele-negative mothers’ rheumatoid arthritis status

Risk allele groupn Proportion of allele-negative mothers with allele-positive childrenRA (mother) OR (95% CI)*p Value
CasesControls
HLA-DRB1
Shared epitope +11/31148/6051.7 (0.8 to 3.7)0.18
DERAA +35/15297/7791.7 (1.0 to 2.7)0.03
Valine + (AA position 11)16/63114/7141.7 (0.9 to 3.3)0.11
Lysine + (AA position 71)26/58127/5832.7 (1.5 to 4.8)0.001
Alanine + (AA position 74)6/8100/1511.4 (0.3 to 7.4)0.70
HLA-B
Aspartic acid + (AA position 9)17/12285/7681.2 (0.7 to 2.2)0.58
HLA-DPB1
Phenylalanine + (AA position 9)8/1049/610.4 (0.04 to 3.7)0.43
  • *95% CI for the association between having at least one child (born prior to diagnosis for cases) with one or two alleles (+) of each risk allele group compared with none and RA among mothers. Estimates adjusted for number of live births and mother’s carrier status at all other risk allele groups.

  • AA, amino acid; RA, rheumatoid arthritis.