Risk allele group (mothers) | Alleles | Cases, N=170 | Controls, N=995 | RA (mother), OR (95% CI)† | p Value |
HLA-DRB1 | n (%) | n (%) | |||
Shared epitope + | *04:01, *04:04, *04:05, *04:08, *01:01, *10:01, *01:02 | 139 (82) | 390 (39) | 5.0 (2.8 to 8.9) | <0.001 |
DERAA + | *04:02, *01:03, *11:02, *13:01, *13:02 | 18 (11) | 216 (22) | 0.7 (0.4 to 1.2) | 0.22 |
Valine + (AA position 11) | *04:01, *04:08, *04:05, *04:04, *10:01, *04:03, *04:07, *04:02 | 107 (63) | 281 (28) | 1.2 (0.7 to 2.0) | 0.50 |
Lysine + (AA position 71) | *04:01, *13:03, *03:01 | 112 (66) | 412 (41) | 1.7 (1.1 to 2.6) | 0.03 |
Alanine + (AA position 74) | *04:01, *04:08, *04:05, *04:04, *10:01, *01:02, *01:01, *16:01, *04:02, *13:03, *15:01, *15:02, *11:01, *11:04, *12:01, *01:03, *11:02, *11:03, *13:01, *13:02 | 162 (95) | 844 (85) | 1.4 (0.6 to 3.2) | 0.46 |
HLA-B | n (%) | n (%) | |||
Aspartic acid + (AA position 9) | *08 | 48 (28) | 227 (23) | 1.3 (0.8 to 2.0) | 0.22 |
HLA-DPB1 | n (%) | n (%) | |||
Phenylalanine + (AA position 9) | *02:01, *02:02, *04:01, *04:02, *05:01, *16:01, *19:01, *23:01 | 160 (94) | 934 (94) | 1.0 (0.5 to 2.1) | 1.0 |
†95% CI for the association between carrying one or two alleles (+) of each risk allele group compared with none and RA among mothers, mutually adjusted.
AA, amino acid; RA, rheumatoid arthritis