Table 1.

Rates of new damage, in subgroups defined by past levels of disease activity

Percentage of prior months in:Number of person-months observedNumber of months with an increase in SLICC/ACR damageRate of damage per 100 person monthsRate ratiosP-values
Clinical Remission
 None35,7724061.131.0 (Ref)
 Not none, but <25%14,3581020.710.60 (0.48, 0.75)<0.0001
 25% to 50%6573500.760.66 (0.46, 0.94)0.023
 50% to 75%3845270.700.63 (0.42, 0.97)0.035
 75%+1,641100.610.58 (0.30, 1.15)0.12
Clinical Remission on Treatment
 None16,4912501.521.0 (Ref)
 Not none, but <25%20,1691700.840.54 (0.44, 0.67)<0.0001
 25% to 50%14,3441030.720.46 (0.36, 0.60)<0.0001
 50% to 75%8396540.640.43 (0.30, 0.60)<0.0001
 75%+2,789180.650.45 (0.27, 0.75)0.0019
LLDAS
 None30,3663431.131.0 (Ref)
 Not none, but <25%10,8801060.970.86 (0.69, 1.07)0.18
 25% to 50%5012400.800.70 (0.51, 0.98)0.037
 50% to 75%8494600.710.63 (0.48, 0.83)
 75%+7,527460.610.54 (0.40, 0.73)<0.0001
LLDAS on Treatment
 None7,6561171.531.0 (Ref)
 Not none, but <25%10,5551341.270.83 (0.65, 1.06)0.14
 25% to 50%12,6861291.020.66 (0.51, 0.85)0.0013
 50% to 75%18,1511330.730.48 (0.37, 0.61)0.0010
 75%+13,141820.620.40 (0.30, 0.54)<0.0001