Rates of new damage, in subgroups defined by past levels of disease activity
| Percentage of prior months in: | Number of person-months observed | Number of months with an increase in SLICC/ACR damage | Rate of damage per 100 person months | Rate ratios | P-values |
|---|---|---|---|---|---|
| Clinical Remission | |||||
| None | 35,772 | 406 | 1.13 | 1.0 (Ref) | |
| Not none, but <25% | 14,358 | 102 | 0.71 | 0.60 (0.48, 0.75) | <0.0001 |
| 25% to 50% | 6573 | 50 | 0.76 | 0.66 (0.46, 0.94) | 0.023 |
| 50% to 75% | 3845 | 27 | 0.70 | 0.63 (0.42, 0.97) | 0.035 |
| 75%+ | 1,641 | 10 | 0.61 | 0.58 (0.30, 1.15) | 0.12 |
| Clinical Remission on Treatment | |||||
| None | 16,491 | 250 | 1.52 | 1.0 (Ref) | |
| Not none, but <25% | 20,169 | 170 | 0.84 | 0.54 (0.44, 0.67) | <0.0001 |
| 25% to 50% | 14,344 | 103 | 0.72 | 0.46 (0.36, 0.60) | <0.0001 |
| 50% to 75% | 8396 | 54 | 0.64 | 0.43 (0.30, 0.60) | <0.0001 |
| 75%+ | 2,789 | 18 | 0.65 | 0.45 (0.27, 0.75) | 0.0019 |
| LLDAS | |||||
| None | 30,366 | 343 | 1.13 | 1.0 (Ref) | |
| Not none, but <25% | 10,880 | 106 | 0.97 | 0.86 (0.69, 1.07) | 0.18 |
| 25% to 50% | 5012 | 40 | 0.80 | 0.70 (0.51, 0.98) | 0.037 |
| 50% to 75% | 8494 | 60 | 0.71 | 0.63 (0.48, 0.83) | |
| 75%+ | 7,527 | 46 | 0.61 | 0.54 (0.40, 0.73) | <0.0001 |
| LLDAS on Treatment | |||||
| None | 7,656 | 117 | 1.53 | 1.0 (Ref) | |
| Not none, but <25% | 10,555 | 134 | 1.27 | 0.83 (0.65, 1.06) | 0.14 |
| 25% to 50% | 12,686 | 129 | 1.02 | 0.66 (0.51, 0.85) | 0.0013 |
| 50% to 75% | 18,151 | 133 | 0.73 | 0.48 (0.37, 0.61) | 0.0010 |
| 75%+ | 13,141 | 82 | 0.62 | 0.40 (0.30, 0.54) | <0.0001 |