Clinical characteristics of patients with GPA and MPA at disease onset according to ANCA specificity
| GPA-PR3 (A) | GPA-MPO (B) | MPA-MPO (C) | p | |
|---|---|---|---|---|
| (n=84) | (n=24) | (n=25) | ||
| Male/female n (%) | 46 (55%)/38 (45%) | 10 (42%)/14 (58%) | 10 (40%)/15 (60%) | 0.29 |
| Age at disease onset (average ± SD) | 49±15 | 55±19 | 63±10 | p<0.001 |
| A vs C p<0.001 | ||||
| B vs C p=0.03 | ||||
| Diagnostic delay (months ± SD) | 7±14 | 17±30 | 10±19 | 0.07 |
| Systemic symptoms | 54 (65%) | 16 (67%) | 19 (76%) | 0.59 |
| ENT | 55 (68%) | 17 (71%) | 4 (17%) | <0.001 |
| Pulmonary | 57 (69%) | 16 (67%) | 16 (64%) | 0.86 |
| Cutaneous | 24 (29%) | 5 (21%) | 1 (4%) | 0.03 |
| Ocular | 16 (20%) | 3 (12%) | 2 (8%) | 0.34 |
| Cardiovascular | 4 (5%) | 2 (9%) | 1 (4%) | 0.77 |
| Gastrointestinal | 2 (3%) | 0 | 0 | 0.56 |
| Renal | 53 (65%) | 11 (46%) | 25 (100%) | <0.001 |
| Nervous system | 26 (31%) | 8 (33%) | 8 (35%) | 0.94 |