| PBO | ABT-981 | PBO | ABT-981 | P | |
|---|---|---|---|---|---|
| 1° Endpoint | Baseline, mean±SD | LS, mean change±SE at Wk 16 | |||
| AUSCAN pain (0–50) | 39±7 | 38±6 | −10.7±2.4 | −9.2±2.3 | 0.39 |
| 2° Endpoints | Baseline, mean±SD | LS, mean change±SE at Wk 26 | |||
| AUSCAN function (0–90) | 69±15 | 71±13 | −14.3±4.2 | −16.4±4.0 | 0.49 |
| Tender joints (0–30) | 12±6 | 12±7 | −4.7±1.2 | −5.8±1.2 | 0.32 |
| Swollen joints (0–30) | 6±6 | 6±5 | −1.8±0.8 | −2.2±0.9 | 0.64 |
| X-ray erosive joints (0–16) | 2±2* | 3±2* | 0.26±0.08† | 0.18±0.08† | 0.33 |
| KL score (0–80) | 41±13 | 46±13 | 0.13±0.19 | 0.10±0.19 | 0.87 |
| OARSI JSN (0–58) | 28±10 | 32±9 | 0.14±0.19 | 0.03±0.19 | 0.51 |
| OARSI osteophytes (0–58) | 23±11 | 26±10 | 0.25±0.15 | 0.14±0.16 | 0.45 |
| HOAMRIS synovitis (sum score; 0–52.5) | 11±4 | 10±4 | 0.92±0.48 | 0.85±0.51 | 0.89 |
| HOAMRIS erosive damage (sum score; 0–105) | 18±9 | 17±10 | 0.26±0.64 | 0.10±0.67 | 0.80 |
| HOAMRIS BML (sum score, 0–105) | 7±5 | 5±4 | 0.11±0.64 | 0.44±0.66 | 0.60 |
*Verbruggen-Veys, erosive phase (E) + erosive with remodeling (E/R) or†new E or E/R or R.