| Type of opportunistic infection | Established RA | Early RA | SIR comparing early RA patients with established RA patients | |||
|---|---|---|---|---|---|---|
| N=226,838 | N=14,081 | |||||
| IR/100PY | 95% CI | IR/100PY | 95% CI | SIR | 95% CI | |
| Total | 3.67 | 3.59–3.74 | 3.81 | 3.52–4.11 | 1.14 | 1.05–1.23 |
| Tuberculosis | 0.71 | 0.67–0.75 | 0.70 | 0.54–0.87 | 1.06 | 0.82–1.33 |
| Herpes zoster | 2.79 | 2.72–2.85 | 2.89 | 2.64–3.13 | 1.12 | 1.03–1.22 |
| Cytomegalovirus | 0.02 | 0.02–0.03 | 0.03 | 0.00–0.06 | 0.98 | 0.20–2.86 |
| Epstein–Barr virus | 0.01 | 0.00–0.01 | 0.04 | 0.00–0.07 | 3.54 | 0.96–9.06 |
| Pneumocystis jiroveci pneumonia (PJP) | 0.01 | 0.01 - 0.02 | 0.02 | -0.01–0.04 | 1.20 | 0.15–4.34 |
| Candidiasis | 0.10 | 0.08–0.11 | 0.11 | 0.07–0.16 | 2.40 | 1.55–3.54 |
| Aspergillosis | 0.02 | 0.02–0.03 | 0.02 | 0.00–0.05 | 0.84 | 0.17–2.47 |
| Cryptococcosis | 0.01 | 0.00–0.01 | 0.01 | -0.01–0.02 | 1.15 | 0.03–6.39 |
RA = rheumatoid arthritis, SIR = standardized incidence ratio, PY = person year, N = number, IR = incidence rate, CI = confidence interval.