Outcome variableDiuretic therapyp
NoYes
Whole sample (N=209)N=117n=92
– SUA reduction (mg/dL), mean (SD)3.2 (2.1)3.7 (2.5)0.196
– SUA<6 (%)80.0%75.9%0.458
– SUA<5 (%)61.0%50.6%0.126
– SUA<4 (%)31.4%28.9%0.575
Allopurinol (n=158)N=92N=66
– SUA reduction (mg/dL), mean (SD)3.1 (1.9)3.2 (2.0)0.813
– SUA<6 (%)80.6%74.2%0.337
– SUA<5 (%)60.2%43.9%0.043
– SUA<4 (%)28.0%21.2%0.334
– Maximum dose (mg/day), mean (SD)316.5 (126.9)278.6 (121.8)0.053
Febuxostat (n=33)N=14N=19
– SUA reduction (mg/dL), mean (SD)3.7 (3.4)5.6 (3.1)0.147
– SUA<6 (%)70.0%82.4%0.456
– SUA<5 (%)70.0%76.5%0.711
– SUA<4 (%)60.0%58.8%0.952
– Maximum dose (mg/day), mean (SD)80.0 (16.3)80.0 (25.3)0.348