Baseline characteristics of 8310 patients with primary Sjögren's syndrome
| Variable | Patients (%) |
|---|---|
| Gender (female) | 7748 (93.2) |
| Age at diagnosis (n=8270) years | 53.2±14.2 |
| Dry eye | 7660 (92.2) |
| Dry mouth | 7700 (92.7) |
| Abnormal ocular tests | 6228/7273 (85.6) |
| Schirmer’s test | 4903/6203 (79.0) |
| Rose bengal/other ocular dye score | 2460/3302 (74.5) |
| Positive minor salivary gland biopsy | 5305/5984 (88.7) |
| Abnormal oral diagnostic tests | 4843/6063 (79.9) |
| Unstimulated whole salivary flow | 3608/4938 (73.1) |
| Parotid sialography | 702/873 (80.4) |
| Salivary scintigraphy | 2160/2578 (83.8) |
| Positive anti-Ro/La antibodies | 6177/8250 (74.9) |
| Anti-Ro antibodies | 5950/8245 (72.2) |
| Anti-La antibodies | 3599/8215 (43.8) |
| ANA-positive | 6292/7746 (81.2) |
| RF-positive | 3483/7154 (48.7) |
| C3 low | 912/6554 (13.9) |
| C4 low | 846/6540 (12.9) |
| Positive cryoglobulins | 307/4118 (7.5) |
| Ethnicity | |
| White | 6174/7884 (78.3) |
| Asian | 1066/7884 (13.5) |
| Hispanic | 393/7884 (5.0) |
| Black/African-American | 104/7884 (1.3) |
| Others | 147/7884 (1.9) |
| Geolocation | |
| Europe | 6045 (72.7) |
| North (>50°N) | 1393 (16.7) |
| South (<50°N) | 4652 (56.0) |
| America | 1134 (13.6) |
| North (>0°) | 881 (10.6) |
| South (<0°) | 253 (3.0) |
| Asia | 940 (11.3) |
| North (>30°N) | 300 (3.6) |
| South (<30°N) | 640 (7.7) |
| Africa | 45 (0.6) |
| Australia | 146 (1.8) |
ANA, antinuclear antibodies; RF, rheumatoid factor.