Table 4

The association of herpes zoster and all infections with incident giant cell arteritis stratified by time period prior to index date

 Herpes zoster infectionAny infection
Adjusted IRR (95% CI)*p ValueAdjusted IRR (95% CI)*p Value
<1 year†1.32 (0.95 to 1.82)0.101.66 (1.54 to 1.79)<0.01
1–2 years1.11 (0.79 to 1.56)0.551.32 (1.22 to 1.43)<0.01
2–3 years1.00 (0.70 to 1.43)0.991.19 (1.09 to 1.29)<0.01
3–4 years0.92 (0.63 to 1.36)0.691.19 (1.09 to 1.30)<0.01
4–5 years1.15 (0.77 to 1.70)0.491.14 (1.05 to 1.25)<0.01
5–10 years1.36 (1.14 to 1.64)<0.011.26 (1.17 to 1.35)<0.01
>10 years1.18 (0.99 to 1.42)0.071.22 (1.13 to 1.32)<0.01
  • *Adjusted for Charlson Comorbidity Index, alcohol use, smoking history, prior use of immunosuppressive therapies and prior use of oral glucocorticoids.

  • †Including 6 months prior to index date.

  • IRR, incident rate ratio.