TableĀ 3

Characteristics of studies included in the meta-analysis

CohortYearSample sizeCountryEthnicityMean ageType of studyType of OAIncident knee OA criteriaGenotyping methodControlled confounder variablesConclusion
CHECK2016635The NetherlandsCaucasian56Incidence, prospective at 8 yearsKnee OANew-onset KL grade 1SBE and PCR/RFLPGender, age, BMI, WOMAC, contralateral OAHaplogroup J associates with decreased risk
OAI20162579USACaucasian61Incidence, Prospective at eight yearsKnee OANew-onset KL grade 2SBE and PCR/RFLPGender, age, BMI, WOMAC, contralateral OAHaplogroup J associates with decreased risk
  • BMI, body mass index; CHECK, cohort hip and cohort knee; KL, Kellgren and Lawrence; OA, osteoarthritis; SBE, single base extension; OAI, osteoarthritis initiative; RFLP, restriction fragment length polymorphism; WOMAC, Western Ontario and McMaster Universities Arthritis Index.