HRs for incident fracture
| Unadjusted | Age/sex adjusted | Fully adjusted† | ||||||
|---|---|---|---|---|---|---|---|---|
| Number of events | Incidence* | HR | CI | HR | CI | HR | CI | |
| All fractures | ||||||||
| Controls | 49 168 | 92.18 | REF | REF | REF | |||
| PsA | 575 | 99.23 | 1.09 | 1.00 to 1.18 | 1.14 | 1.05 to 1.24 | 1.16 | 1.06 to 1.27 |
| Mild psoriasis | 8470 | 92.38 | 1.01 | 0.98 to 1.03 | 1.09 | 1.07 to 1.12 | 1.07 | 1.05 to 1.10 |
| Severe psoriasis | 537 | 119.91 | 1.33 | 1.22 to 1.45 | 1.42 | 1.30 to 1.55 | 1.26 | 1.15 to 1.39 |
| RA | 3460 | 148.44 | 1.63 | 1.57 to 1.68 | 1.32 | 1.28 to 1.37 | 1.23 | 1.18 to 1.28 |
| Hip fracture | ||||||||
| Controls | 5930 | 10.71 | REF | REF | REF | |||
| PsA | 54 | 8.97 | 0.86 | 0.66 to 1.12 | 1.27 | 0.97 to 1.66 | 1.17 | 0.86 to 1.59 |
| Mild psoriasis | 930 | 9.78 | 0.92 | 0.86 to 0.99 | 1.16 | 1.08 to 1.24 | 1.13 | 1.04 to 1.22 |
| Severe psoriasis | 55 | 11.77 | 1.17 | 0.90 to 1.53 | 1.69 | 1.29 to 2.20 | 1.21 | 0.88 to 1.66 |
| RA | 730 | 29.81 | 2.85 | 2.64 to 3.08 | 1.77 | 1.64 to 1.91 | 1.55 | 1.40 to 1.72 |
| Vertebral fracture | ||||||||
| Controls | 2009 | 3.62 | REF | REF | REF | |||
| PsA | 20 | 3.32 | 0.94 | 0.60 to 1.46 | 1.06 | 0.69 to 1.65 | 1.07 | 0.66 to 1.72 |
| Mild psoriasis | 371 | 3.89 | 1.09 | 0.97 to 1.21 | 1.24 | 1.11 to 1.39 | 1.17 | 1.03 to 1.33 |
| Severe psoriasis | 32 | 6.85 | 2.02 | 1.42 to 2.87 | 2.35 | 1.66 to 3.33 | 2.23 | 1.54 to 3.22 |
| RA | 209 | 8.48 | 2.40 | 2.08 to 2.76 | 1.70 | 1.48 to 1.96 | 1.53 | 1.30 to 1.80 |
The fully adjusted models for each outcome were slightly different after employing a purposeful selection process. The variables contained within each model are specified as below.
*Incidence per 10 000 person-years.
†The all fracture model was adjusted for age, sex, cancer, atrial fibrillation, CKD, diabetes, COPD, liver disease, stroke, dementia, SSRI use, TCA use, antiepileptic use, PPI use, oral steroids, hormone treatment, ciclosporine, smoking and categorical BMI.
‡The hip fracture model was adjusted for age, sex, cancer, atrial fibrillation, CKD, CVD, diabetes, COPD, stroke, dementia, SSRI use, TCA use, antiepileptic use, oral steroids, hormone treatment, ciclosporine, smoking and categorical BMI.
§The vertebral fracture model was adjusted for age, sex, atrial fibrillation, diabetes, COPD, stroke, SSRI use, TCA use, PPI use, oral steroids, smoking and categorical BMI.
BMI, body mass index; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; CVD, cardiovascular disease; PPI, proton pump inhibitor; PsA, psoriatic arthritis; RA, rheumatoid arthritis; SSRI, selective serotonin reuptake inhibitor; TCA, tricyclic antidepressant.