Time-dependent treatment variables | Unadjusted HR (95% CI) | p Value | Adjusted HR* (95% CI) | p Value |
---|---|---|---|---|
Statins | 1.73 (1.52 to 1.97) | <0.001 | 1.56 (1.36 to 1.78) | <0.001 |
Glucocorticoids | 1.43 (1.26 to 1.61) | <0.001 | 1.31 (1.15 to 1.49) | <0.001 |
HCQ | 0.66 (0.55 to 0.78) | <0.001 | 0.67 (0.57 to 0.80) | <0.001 |
DMARD groups | ||||
MTX monotherapy (referent) | 1.0 | – | 1.0 | – |
Any abatacept | 0.82 (0.52 to 1.29) | 0.39 | 0.52 (0.31 to 0.89) | 0.017 |
Any other DMARD with MTX | 0.98 (0.82 to 1.18) | 0.88 | 0.87 (0.72 to 1.05) | 0.158 |
Other or no DMARDs | 1.36 (1.17 to 1.58) | <0.001 | 1.11 (0.95 to 1.31) | 0.190 |
*Adjusted for age, sex, disease duration, socioeconomic status (employment and income), ethnicity, smoking, hypertension, comorbidity index, BMI, HAQ, NSAID usage and year of entry.
BMI, body mass index; DMARD, disease-modifying antirheumatic drug; HAQ, health assessment questionnaire; HCQ, hydroxychloroquine; MTX, methotrexate; NSAID, non-steroidal anti-inflammatory drug; RA, rheumatoid arthritis.