Association of P97 residues of HLA-B with AS
| P97 residues | Association with AS | OR* | p Value* | Examples of HLA-B allele |
|---|---|---|---|---|
| N | Risk | 16.51 | <10−300 | *27:05 |
| T | Risk | 1.12 | 4.5×10−3 | *51:01 *13:02 |
| R | Non-associated | 1 | 1 | *15:01 *40:01 *47:01 |
| W | Non-associated | 1 | 0.95 | *14:01 |
| S | Protective | 0.86 | 4.81×10−8 | *07:02 *40:02 |
| V | Protective | 0.68 | 1.41×10−8 | *57:01 |
| D | Synthetic | N/A | N/A | N/A |
*Statistics from Cortes et al,2 Fisher's exact test used for p value. The HLA-B allotypes investigated in the current study, HLA-B*27:05, HLA-B*51:01 and HLA-B*07:01, are highlighted in bold. Of note, aspartic acid (D) is not present in P97 of HLA-B.
AS, ankylosing spondylitis; HLA, human leucocyte antigen; P97, position 97.