Baseline characteristics
| csDMARD n=3367 | All TNFi n=11 931 | p Value | |
|---|---|---|---|
| Mean age: years (SD) | 60 (12) | 56 (12) | <0.001 |
| Females: % | 2477 (74) | 9115 (76) | <0.001 |
| Smoking history n (%) | |||
| Current smoker | 795 (24) | 2595 (22) | 0.001 |
| Former smoker | 1335 (40) | 4530 (38) | |
| Never smoked | 1222 (36) | 4727 (40) | |
| Not recorded | 15 (0) | 79 (1) | |
| Ethnicity n (%) | |||
| White | 2561 (76) | 9848 (83) | <0.001 |
| Other | 64 (2) | 410 (3) | |
| Not recorded | 742 (22) | 1673 (14) | |
| Mean DAS28 (SD) | 5.3 (1.1) | 6.6 (0.9) | <0.001 |
| Mean HAQ (SD) | 1.5 (0.7) | 2.0 (0.6) | <0.001 |
| Median disease duration: years (IQR) | 6 (1, 15) | 11 (6 19) | <0.001 |
| Baseline steroid use: n (%) | 759 (23) | 5259 (44) | <0.001 |
| Number of prior csDMARD: median (IQR) | 2 (1, 3) | 4 (3, 5) | <0.001 |
| Comorbidity*: n (%) | |||
| None | 1397 (41) | 5530 (46) | <0.001 |
| 1 comorbidity | 1163 (35) | 4098 (34) | |
| 2 comorbidities | 560 (17) | 1691 (14) | |
| ≥3 comorbidities | 247 (7) | 612 (5) | |
| Prior solid cancer: n (%) | 122 (4) | 170 (1) | <0.001 |
*Hypertension, ischaemic heart disease (myocardial infarction or angina), stroke, lung disease (asthma, bronchitis or emphysema), diabetes mellitus, depression, renal disease and liver disease.
csDMARD, non-biological (synthetic) disease-modifying drug; DAS28, 28-joint Disease Activity Score; HAQ, Health Assessment Questionnaire; TNFi, tumour necrosis factor inhibitors.