Table 4

Association between DMARD-treated RA and all-cause mortality according to time period

1999–20062007–2014
RA cohort
(n=5775)
Non-RA cohort
(n=28 653)
RA cohort
(n=7922)
Non-RA cohort
(n=39 059)
p for interaction
Mean follow-up (PYs)3.20±2.133.21±2.153.38±2.193.32±2.20
Deaths (n)41513533811528
Death rate/1000 PYs (95% CI)22.5 (20.4 to 24.8)14.7 (13.9 to 15.5)14.2 (12.8 to 15.7)11.8 (11.2 to 12.4)
Age-matched, sex-matched and entry year-adjusted rate ratio (95% CI)1.54 (1.37 to 1.72)1.00 (Ref)1.21 (1.08 to 1.36)1.00 (Ref)<0.01
Multivariable-adjusted rate ratio (95% CI)*1.50 (1.33 to 1.69)1.00 (Ref)1.15 (1.02 to 1.29)1.00 (Ref)<0.01
Age-matched, sex-matched and entry year-adjusted rate difference/1000 PYs (95% CI)7.8 (5.5 to 10.0)0.0 (Ref)2.4 (0.9 to 3.9)0.0 (Ref)<0.01
Multivariable-adjusted rate difference/1000 PYs (95% CI)*5.5 (3.0 to 8.0)0.0 (Ref)1.5 (−0.1 to 3.2)0.0 (Ref)<0.01
  • *In addition to the matching variables, multivariable models were adjusted for the number of GP visits, BMI, smoking status (ie, non-smokers, ex-smokers and current smokers), alcohol consumption (ie, non-drinkers, ex-drinkers and current drinkers), comorbidities and medication use prior to the index date.

  • BMI, body mass index; DMARD, disease-modifying anti-rheumatic drug; GP, general practitioner; PY, person-year; RA, rheumatoid arthritis.