Clinical findings of family members affected with chilblain lupus
Characteristic | Patient I.1 | Patient II.1 | Patient II.2 | Patient III.2 | Patient IV.3 |
---|---|---|---|---|---|
Current age | 86 years | 60 years | 58 years | 36 years | 12 years |
Age of onset | 6 years | 3 years | 2 months | 12 years | 10 years |
Chilblain lesions on fingers, toes, nose and ears | + | + | + | − | + |
Ischaemia of fingers and toes | + | + | + | − | − |
Ischaemia of nose and ears | + | + | + | + | − |
Nail dystrophy or nail loss | − | + | + | − | − |
Chilblain lesions on thighs | + | − | + | + | − |
Abnormal nailfold capillaries | + | ND | + | + | + |
ANA | 1:160 | 1:160 | 1:160 | 1:80 | − |
anti-C1q | − | − | >200 U/mL (<20 U/mL) | − | − |
ANA, antinuclear antibodies; ND, not determined.