Clinical findings of family members affected with chilblain lupus
| Characteristic | Patient I.1 | Patient II.1 | Patient II.2 | Patient III.2 | Patient IV.3 |
|---|---|---|---|---|---|
| Current age | 86 years | 60 years | 58 years | 36 years | 12 years |
| Age of onset | 6 years | 3 years | 2 months | 12 years | 10 years |
| Chilblain lesions on fingers, toes, nose and ears | + | + | + | − | + |
| Ischaemia of fingers and toes | + | + | + | − | − |
| Ischaemia of nose and ears | + | + | + | + | − |
| Nail dystrophy or nail loss | − | + | + | − | − |
| Chilblain lesions on thighs | + | − | + | + | − |
| Abnormal nailfold capillaries | + | ND | + | + | + |
| ANA | 1:160 | 1:160 | 1:160 | 1:80 | − |
| anti-C1q | − | − | >200 U/mL (<20 U/mL) | − | − |
ANA, antinuclear antibodies; ND, not determined.