Table 3

Association between RA and all-cause mortality by sex and time period

1999–20062007–2014
RA cohortNon-RA cohortRA cohortNon-RA cohortp for interaction
Men300614 992338216 878
Death rate/1000 PYs (95% CI)37.0 (33.2 to 41.0)23.0 (21.6 to 24.3)22.3 (19.6 to 25.3)17.8 (16.7 to 19.0)
Multivariable-adjusted rate ratio (95% CI)*1.51 (1.32 to 1.72)1.00 (Ref)1.21 (1.04 to 1.41)1.00 (Ref)0.02
Multivariable-adjusted rate difference/1000 PYs (95% CI)*12.1 (7.4 to 16.8)0.0 (Ref)3.5 (0.1 to 6.9)0.0 (Ref)<0.01
Women712035 554738736 871
Death rate/1000 PYs (95% CI)25.8 (23.7 to 27.9)16.0 (15.3 to 16.7)14.7 (13.2 to 16.3)10.8 (10.2 to 11.4)
Multivariable-adjusted rate ratio (95% CI)*1.60 (1.44 to 1.77)1.00 (Ref)1.34 (1.19 to 1.52)1.00 (Ref)<0.01
Multivariable-adjusted rate difference/1000 PYs (95% CI)*8.5 (6.2 to 10.8)0.0 (Ref)2.9 (1.2 to 4.6)0.0 (Ref)<0.01
  • *In addition to the matching variables, multivariable models were adjusted for the number of GP visits, BMI, smoking status (ie, non-smokers, ex-smokers and current smokers), alcohol consumption (ie, non-drinkers, ex-drinkers and current drinkers), comorbidities and medication use prior to the index date.

  • BMI, body mass index; GP, general practitioner; PY, person-year; RA, rheumatoid arthritis.