Patient characteristics at baseline
| IMPACT II | GO-REVEAL | Combined | |
|---|---|---|---|
| Patient N | 130 | 310 | 440 |
| Age (year) | 47.6 (11.8) | 46.4 (10.6) | 46.8 (11.0) |
| Female (%) | 39.2 | 42.3 | 41.4 |
| Disease duration (years) | 8.5 (7.4) | 7.4 (7.4) | 7.8 (7.4) |
| Health Assessment Questionnaire | NA | 1.0 (0.6) | 1.0 (0.6) |
| Patient global assessment | 56.4 (22.3) | 53.1 (22.9) | 54.1 (22.8) |
| Evaluator global assessment | 55.8 (17.5) | 54.2 (17.8) | 54.7 (17.7) |
| Pain scores | 56.9 (22.9) | 55.7 (23.8) | 56.0 (23.5) |
| SF-36 Mental Component Score | 45.6 (11.9) | 45.5 (11.7) | 45.5 (11.7) |
| SF-36 Physical Component Score | 33.0 (9.24) | 32.5 (9.81) | 32.6 (9.64) |
| C-reactive protein (mg/L) | 2.1 (3.1) | 1.4 (1.6) | 1.6 (2.2) |
| Swollen joint count 28 | 6.48 (4.35) | 7.55 (5.55) | 7.23 (5.24) |
| Tender joint count 28 | 8.52 (5.77) | 10.5 (7.56) | 9.90 (7.13) |
| Swollen joint count 66* | 11.3 (7.11) | 13.4 (10.5) | 12.8 (9.66) |
| Tender joint count 68* | 19.7 (12.7) | 23.0 (16.6) | 22.0 (15.6) |
| Simplified Disease Activity Index | 28.4 (10.4) | 30.2 (13.8) | 29.7 (12.9) |
| Clinical Disease Activity Index | 26.3 (9.72) | 28.9 (13.6) | 28.1 (12.6) |
| Disease Activity Score 28 (CRP) | 4.27 (0.89) | 4.91 (1.07) | 4.73 (1.06) |
| DAPSA | 44.6 (17.9) | 48.8 (26.4) | 47.6 (24.3) |
| SvdH total radiographic score† | 30.6 (68.5) | 21.0 (33.3) | 23.8 (46.7) |
| SvdH erosion score† | 16.0 (38.7) | 12.6 (19.5) | 13.6 (26.7) |
| SvdH joint space narrowing score† | 14.5 (30.4) | 8.39 (14.7) | 10.2 (20.8) |
*In addition to the joints assessed by the 28 joint count, the 68 joint count includes the assessment of the ankle, tarsus, MCP I–V of the feet, IP I of the feet, DIP II–V of the feet, DIP II–V of the hands, acromioclavicular joint, sternoclavicular joint, temporomandibular joint, the hip (only for tenderness).
†The SvdH Score for PsA is a modification of the RA score expanded by the DIPs of the hands, and includes the feature of malalignment, and thus ranges from 0 to 528.
DAPSA, Disease Activity index for PSoriatic Arthritis; DIP, distal interphalangeal joints; IP I, interphalangeal joint I; MCP, metacarpo-phalangeal joints; PsA, psoriatic arthritis; SvdH, Sharp/van der Heijde.