Table 1

Serum levels of interleukin (IL)-1β, IL-6, interferon γ (IFNγ) and of the three IFNγ-related chemokines CXCL9, CXCL10 and CXCL11 in patients with active secondary haemophagocytic lymphohistiocytosis (sec-HLH), with active macrophage activation syndrome (MAS) at sampling, with active systemic juvenile idiopathic arthritis (sJIA) without MAS at sampling and with clinically inactive sJIA

sec-HLH (n=11)sJIA with MAS at sampling (n=20)Active sJIA without MAS (n=28)Inactive sJIA (n=35)sec-HLH vs MAS
p Value
MAS vs Active sJIA without MAS
p Value
IL-1β<3.5<3.5<3.5<3.50.690.86
(pg/mL)(<3.5–10.7)(<3.5–6.1)(<3.5–3.8)(<3.5–3.5)
IL-611.422.920.3*3.20.560.43
(pg/mL)(3.2–49.3)(5.5–45.6)(5.9–54.9)(3.2–7.9)
IFNγ34.715.44.94.20.120.03
(pg/mL)(23.9–170.1)(5.1–52.6)(3.2–8.6)(3.2–9.3)
CXCL933 59813 3928379010.230.005
(pg/mL)(3083–127 687)(2163–35 452)(471–2505)(466–1213)
CXCL10442016123072350.190.0016
(pg/mL)(799–8226)(425–4309)(199–694)(172–407)
CXCL1113275651221110.300.003
(pg/mL)(189–2000)(198–1007)(62–197)(63–187)
  • Values are shown as median (IQR).

  • *Active sJIA versus clinical inactive sJIA: p<0.01.