Table 2

Associations between summated scores of MR imaging features and progression of radiographic osteoarthritis on patient level in 87 hand osteoarthritis patients*

MR featureKL progression (95% CI)Osteophyte progression (95% CI)JSN progression (95% CI)
Patients with progression/total44/8747/8734/87
BML (0–24)
 Crude RR1.08 (1.01 to 1.2)1.05 (0.98 to 1.1)1.11 (1.02 to 1.2)
 RR adjusted for synovitis1.00 (0.9 to 1.1)1.01 (0.9 to 1.1)1.00 (0.9 to 1.1)
 RR adjusted age, sex and BMI1.06 (0.99 to 1.1)1.07 (0.98 to 1.2)1.11 (1.01 to 1.2)
Synovitis (0–24)
 Crude RR1.09 (1.04 to 1.1)1.05 (1.004 to 1.1)1.13 (1.1 to 1.2)
 RR adjusted for BML1.09 (1.04 to 1.2)1.05 (0.99 to 1.1)1.12 (1.05 to 1.2)
 RR adjusted age, sex and BMI1.08 (1.03 to 1.1)1.07 (1.02 to 1.1)1.14 (1.1 to 1.2)
  • *RRs should be interpreted as increased risk per point increase in summated BML or synovitis scores. For example, our observed range for summated BML score was 0–10, so patients with the highest BML score have a 1.0810=2.16 times (216%) higher risk for KL progression than patients without any BML.

  • BMI, body mass index; BML, bone marrow lesion; JSN, joint space narrowing; KL, Kellgren-Lawrence; RR, risk ratio.