Correlation of laboratory parameters of disease activity with levels of interferon γ (IFNγ), CXCL9, CXCL10, CXCL11, interleukin (IL)-6 and IL-1β in patients with macrophage activation syndrome (MAS) and in patients with active systemic juvenile idiopathic arthritis (sJIA) without MAS at sampling
| IFNγ | CXCL9 | CXCL10 | CXCL11 | IL-6 | IL-1β | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| r* | p Value | r* | p Value | r* | p Value | r* | p Value | r* | p Value | r* | p Value | ||
| MAS | |||||||||||||
| Ferritin (ng/mL) | 8000 (3158–13 174)† | 0.57 | 0.014 | 0.49 | 0.041 | 0.66 | 0.002 | 0.62 | 0.023 | 0.17 | >0.1 | −0.11 | >0.1 |
| Neutrophils (×109/L) | 6.9 (3.4–13.9)† | −0.64 | 0.005 | −0.61 | 0.010 | −0.37 | >0.1 | −0.08 | >0.1 | 0.09 | >0.1 | −0.37 | >0.1 |
| Platelets (×109/L) | 197 (114–392)† | −0.53 | 0.017 | −0.52 | 0.022 | −0.58 | 0.008 | −0.22 | >0.1 | −0.02 | >0.1 | −0.30 | >0.1 |
| ALT (U/L) | 46 (18–164)† | 0.49 | 0.045 | 0.49 | 0.044 | 0.51 | 0.038 | 0.06 | >0.1 | −0.44 | 0.080 | 0.22 | >0.1 |
| LDH (U/L) | 1152 (722–2135)† | 0.45 | 0.095 | 0.62 | 0.013 | 0.64 | 0.001 | 0.64 | 0.048 | 0.08 | >0.1 | 0.37 | >0.1 |
| Active sJIA without MAS | |||||||||||||
| Ferritin (ng/mL) | 214 (37–1669)† | −0.27 | >0.1 | 0.28 | >0.1 | 0.27 | >0.1 | 0.29 | >0.1 | −0.12 | >0.1 | 0.14 | >0.1 |
| Neutrophils (×109/L) | 8.4 (5.2–14.5)† | 0.30 | >0.1 | 0.40 | 0.061 | 0.32 | >0.1 | 0.40 | 0.067 | 0.28 | >0.1 | −0.07 | >0.1 |
| Platelets (×109/L) | 444 (353–544)† | 0.21 | >0.1 | −0.14 | >0.1 | −0.13 | >0.1 | 0.27 | >0.1 | 0.35 | 0.064 | −0.03 | >0.1 |
| ALT (U/L) | 16 (11–24)† | 0.29 | >0.1 | 0.42 | 0.049 | 0.50 | 0.011 | 0.44 | 0.039 | 0.04 | >0.1 | 0.07 | >0.1 |
| LDH (U/L) | 506 (455–851)† | 0.07 | >0.1 | 0.49 | >0.1 | 0 | >0.1 | 0.26 | >0.1 | 0 | >0.1 | 0.07 | >0.1 |
*Spearman correlation coefficient.
†Median (IQR).
ALT, alanine aminotransferase; LDH, lactate dehydrogenase.