Table 2

Diagnostic accuracy of ACPA for prevalent rheumatoid arthritis (RA) at inclusion

Diagnostic accuracy of the anti-CCP2 test
Sensitivity
TestResultRANo RA(95% CI)SpecificityPPVNPVPLRNLR
Anti-CCP2 testPositive10324766.0% (58.6 to 73.5)98.0% (97.8 to 98.3)29.4% (24.7 to 34.2)99.6% (99.5 to 99.7)33.2 (27.7 to 38.8)0.35 (0.27 to 0.42)
Negative5312 187
High anti-CCP2 cut-offPositive9710562.2% (54.6 to 69.8)99.2% (99.0 to 99.3)48.0% (41.1 to 54.9)99.5% (99.4 to 99.6)74 (57.0 to 90.3)0.38 (0.30 to 0.46)
Negative5912 329
  • ACPA, Anti-citrullinated protein antibodies; NLR, negative likelihood ratio; NPV, negative predictive value; PLR, positive likelihood ratio; PPV, positive predictive value.