Table 2

Recalibrated and extended UK FRAX for 10-year risk of hip fracture (CPRD-HES) in RA

β-coefficientOR (95% CI)Shrunken β-coefficient*
Recalibrated UK FRAX
 UK FRAX†0.7572.13 (1.92 to 2.37)0.749
Extended UK FRAX
 UK FRAX†0.9392.56 (2.17 to 3.02)0.921
 Secondary osteoporosis (yes/no)0.5211.68 (1.04 to 2.74)0.511
 Glucocorticoid >7.5 mg/day (yes/no)−1.3030.27 (0.09 to 0.87)−1.276
 Duration of RA disease (per year increase)−0.0290.97 (0.95 to 0.99)−0.029
 Duration of RA disease† UK FRAX†−0.0150.99 (0.98 to 0.99)−0.015
  • *The shrunken β-coefficients were derived by applying the shrinkage factor (0.98 for the extended model and 0.99 for the recalibrated model) to the original β-coefficients.

  • †Log odds transformed 10-year risks of hip fracture (ln(probhip/(1 − probhip)) as derived from the original UK FRAX algorithm.

  • CPRD, Clinical Practice Research Datalink; HES, Hospital Episode Statistics; RA, rheumatoid arthritis.