Table 4

Cut-off of disease activity levels and minimal clinically important improvement (MCII) with ClinESSDAI

Activity levels cut-offs
At baselineAt 6 months
Moderate activity threshold
 -ROC curve analysis55
 AUC0.830.83
 Sensitivity/specificity67.7%/80.0%70.3%/76.9%
 -Anchoring method
  75th percentile of the distribution in MDA group8 (6; 8)6 (5 ;7)
High activity threshold
 -ROC curve1414
 AUC0.960.93
 Sensitivity/specificity92.9.0%/83.3%91.8%/75.0%
Anchoring method
 -In non-MDA group
  75th percentile of the distribution14 (13 ; 18)11 (9; 15)
MCII (95% CI)
In the whole cohort−3 (−5 to −2)
Among patients with ESSDAI≥5 at baseline−4 (−7 to −2)
  • AUC, area under the curve; ClinESSDAI, Clinical ESSDAI (ie, without the biological domain); ESSDAI, EULAR Sjögren's Syndrome Disease Activity Index; EULAR, European League Against Rheumatism; MDA, minimal disease activity; ROC, receiver operating characteristic.