Number of deaths (n) and HR (95% CI) of all-cause and disease-specific mortality by knee OA categories
| Outcome Knee OA status | No. of deaths (%) | Model 1 | p Value | Model 2 | p Value | Model 3 | p Value | |||
|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | HR | 95% CI | HR | 95% CI | |||||
| All-causes | ||||||||||
| Neither ROA nor pain | 84 (16.0) | 1.00 | 1.00 | 1.00 | ||||||
| ROA only | 14 (21.9) | 0.95 | 0.54 to 1.69 | 0.865 | 1.01 | 0.57 to 1.80 | 0.968 | 1.05 | 0.58 to 1.88 | 0.876 |
| Pain only | 46 (26.1) | 1.49 | 1.04 to 2.14 | 0.029 | 1.55 | 1.07 to 2.22 | 0.019 | 1.44 | 0.99 to 2.08 | 0.055 |
| Painful ROA | 22 (38.6) | 1.97 | 1.23 to 3.17 | 0.005 | 2.06 | 1.27 to 3.33 | 0.003 | 1.97 | 1.20 to 3.22 | 0.007 |
| CVD disease | ||||||||||
| Neither ROA nor pain | 17 (3.2) | 1.00 | 1.00 | 1.00 | ||||||
| ROA only | 4 (6.3) | 1.14 | 0.38 to 3.43 | 0.811 | 1.47 | 0.48 to 4.49 | 0.498 | 1.45 | 0.47 to 4.48 | 0.521 |
| Pain only | 18 (10.2) | 2.78 | 1.43 to 5.41 | 0.003 | 3.25 | 1.64 to 6.43 | 0.001 | 2.93 | 1.47 to 5.85 | 0.002 |
| Painful ROA | 10 (17.5) | 3.98 | 1.81 to 8.76 | 0.001 | 4.19 | 1.87 to 9.40 | 0.001 | 3.57 | 1.53 to 8.34 | 0.003 |
| Cancer disease | ||||||||||
| Neither ROA nor pain | 44 (8.4) | 1.00 | 1.00 | 1.00 | ||||||
| ROA only | 7 (10.9) | 1.08 | 0.48 to 2.41 | 0.860 | 1.11 | 0.49 to 2.51 | 0.801 | 1.10 | 0.48 to 2.51 | 0.818 |
| Pain only | 19 (10.8) | 1.23 | 0.72 to 2.12 | 0.444 | 1.23 | 0.72 to 2.12 | 0.451 | 1.12 | 0.64 to 1.94 | 0.693 |
| Painful ROA | 6 (10.5) | 1.17 | 0.49 to 2.78 | 0.719 | 1.33 | 0.56 to 3.16 | 0.523 | 1.18 | 0.49 to 2.88 | 0.712 |
Model 1: adjusted for age.
Model 2: Model 1+Smoking, total cholesterol, HDL-cholesterol, systolic BP and BP medication (Framingham Risk Score Factors).
Model 3: Model 2+occupation, BMI, HRT use, past physical activity, current/previous CVD disease, non-ASA NSAIDs and glucose levels.
BMI, body mass index; BP, blood pressure; CVD, cardiovascular disease; HDL, High-density lipoprotein; HRT, hormone replacement therapy; NSAIDs, non-steroidal anti-inflammatory drugs; OA, osteoarthritis; ROA, radiographic osteoarthritis.