Results of multivariable Cox regression analysis of clinical and serological factors and MRI-detected subclinical inflammation at baseline in relation to arthritis development
| HR (95% CI) | p Value | |
|---|---|---|
| Age, per year | 0.96 (0.93 to 0.996) | 0.028 |
| Localisation of initial symptoms | ||
| Small joints only | Ref | Ref |
| Large joints only | 2.35 (0.41 to 13.61) | 0.34 |
| Small and large joints | 4.30 (1.70 to 10.86) | 0.002 |
| CRP level, per mg/L | 1.05 (1.01 to 1.09) | 0.021 |
| ACPA-positive | 6.43 (2.57 to 16.05) | <0.001 |
| Presence of any MRI-detected inflammation | 5.07 (1.77 to 14.50) | 0.002 |
Presented are the HRs of multivariable analyses including 142 patients with clinically suspect arthralgia that underwent MRI of which 27 developed the outcome clinical arthritis. One patient that underwent MRI had missing data on localisation of initial symptoms and was not included in present analysis.
ACPA, anticitrullinated peptide antibodies; CRP, C reactive protein; ref, reference.