Unadjusted T cell analysis of progression to IA
| Reduced naïve cell frequency | Elevated IRC frequency | Reduced Treg frequency | |
|---|---|---|---|
| Observed proportion of patients (observed/n) | 22.5% | 30.3% | 35.4% |
| 23/102 | 30/99 | 35/99 | |
| Calculated proportion* | 22.1% | 29.5% | 35.8% |
| 95% CI | 14.2% to 31.8 | 20.6% to 39.7 | 26.2% to 46.3 |
| Standardised binomial test z | 7.4 | 10.7 | 13.5 |
| p Value | <0.001 | <0.001 | <0.001 |
| AUROC* | 0.63 | 0.63 | 0.66 |
| 95% CI | 0.52 to 0.74 | 0.52 to 0.74 | 0.55 to 0.77 |
| p Value | 0.029 | 0.032 | 0.008 |
| Sensitivity* | 28.6 % | 35.7 % | 45.2 % |
| 95% CI | 17.2 to 43.6 | 23.0 to 50.8 | 31.2 to 60.1 |
| Specificity* | 83 % | 75.5 % | 71.7 % |
| 95% CI | 70.8 to 90.8 | 62.4 to 85.1 | 58.4 to 82.0 |
| Naïve (per %)† | IRC (per %) | Treg (per %)† | |
| Unadjusted OR* | 0.94 | 1.15 | 0.70 |
| 95% CI | 0.90 to 0.98 | 1.00 to 1.32 | 0.56 to 0.89 |
*In patients with data for all three T cell subsets n=95.
†Adjusted for age.AUROC, area under the ROC curve; IA, inflammatory arthritis; IRC, inflammation related cell; Treg, regulatory T cells.