Table 4

Number of deaths (n) and HR (95% CI) of all-cause and disease-specific mortality by hand OA categories

Outcome Hand OA status	No. of deaths (%)	Model 1		p Value	Model 2		p Value	Model 3		p Value
Outcome Hand OA status	No. of deaths (%)	HR	95% CI	p Value	HR	95% CI	p Value	HR	95% CI	p Value
All-causes
Neither ROA nor pain	66 (15.9)	1.00			1.00			1.00
ROA only	43 (25.9)	0.94	0.62 to 1.41	0.754	0.86	0.57 to 1.30	0.465	0.91	0.60 to 1.39	0.667
Pain only	23 (18.1)	1.02	0.64 to 1.65	0.920	1.02	0.63 to 1.64	0.947	0.98	0.60 to 1.60	0.946
Painful ROA	31 (31.3)	1.13	0.72 to 1.77	0.591	1.05	0.67 to 1.65	0.835	1.05	0.66 to 1.66	0.850
CVD disease
Neither ROA nor pain	18 (4.3)	1.00			1.00			1.00
ROA only	10 (6.0)	0.60	0.27 to 1.34	0.212	0.48	0.21 to 1.10	0.081	0.57	0.25 to 1.33	0.196
Pain only	10 (7.9)	1.54	0.71 to 3.33	0.276	1.66	0.75 to 3.66	0.210	1.53	0.67 to 3.50	0.313
Painful ROA	8 (8.1)	0.80	0.34 to 1.91	0.620	0.76	0.32 to 1.82	0.541	0.75	0.30 to 1.87	0.539
Cancer disease
Neither ROA nor pain	33 (7.9)	1.00			1.00			1.00
ROA only	22 (13.3)	1.28	0.71 to 2.29	0.407	1.24	0.69 to 2.24	0.477	1.27	0.70 to 2.30	0.432
Pain only	9 (7.1)	0.85	0.41 to 1.78	0.665	0.83	0.39 to 1.75	0.626	0.78	0.34 to 1.66	0.522
Painful ROA	12 (12.1)	1.17	0.58 to 2.35	0.662	1.13	0.55 to 2.29	0.743	1.16	0.57 to 2.39	0.679

Model 1: adjusted for age.
Model 2: Model 1+Smoking, total cholesterol, HDL-cholesterol, systolic BP and BP medication (Framingham Risk Score Factors).
Model 3: Model 2+occupation, BMI, HRT use, past physical activity, current/previous CVD disease, non-ASA NSAIDs and glucose levels.
BMI, body mass index; BP, blood pressure; CVD, cardiovascular disease; HDL, High-density lipoprotein; HRT, hormone replacement therapy; NSAIDs, non-steroidal anti-inflammatory drugs; OA, osteoarthritis; ROA, radiographic osteoarthritis.