Change in bone area and shape in progressor knees versus being in a reference group of knees having no radiographic and no pain progression (group 4, n=200) (method 1)
| Radiographic and pain progressor (group 1, n=194) | Pain only progressor (group 2, n=103) | Radiographic only progressor (group 3, n=103) | |
|---|---|---|---|
| Medial | |||
| Femur | 2.69 (2.03 to 3.56); <0.0001 | 1.13 (0.81 to 1.57); 0.4682 | 2.86 (2.09 to 3.92); <0.0001 |
| Tibia | 1.84 (1.45 to 2.33); <0.0001 | 1.07 (0.81 to 1.43); 0.6326 | 2.00 (1.52 to 2.62); <0.0001 |
| Patella | 1.57 (1.25 to 1.97); <0.0001 | 1.12 (0.86 to 1.45); 0.4132 | 1.38 (1.06 to 1.80); 0.0156 |
| Lateral | |||
| Femur | 1.38 (1.11 to 1.71); 0.0043 | 1.06 (0.82 to 1.37); 0.6749 | 1.21 (0.94 to 1.56); 0.1421 |
| Tibia | 1.79 (1.42 to 2.24); <0.0001 | 1.01 (0.77 to 1.33); 0.9426 | 1.67 (1.29 to 2.18); 0.0001 |
| Patella | 1.67 (1.33 to 2.10); <0.0001 | 1.14 (0.87 to 1.48); 0.3403 | 1.45 (1.10 to 1.90); 0.0076 |
| Notch | 1.59 (1.27 to 1.99); <0.0001 | 1.16 (0.88 to 1.51); 0.2884 | 1.78 (1.37 to 2.31); <0.0001 |
| Lateral | |||
| Trochlea | 1.60 (1.29 to 2.00); <0.0001 | 0.98 (0.75 to 1.28); 0.9034 | 1.39 (1.07 to 1.79); 0.0119 |
| Medial | |||
| Trochlea | 2.07 (1.61 to 2.67); <0.0001 | 1.04 (0.76 to 1.41); 0.8164 | 1.99 (1.50 to 2.64); <0.0001 |
| Vector (shape) | |||
| Femur | 2.34 (1.79 to 3.06); <0.0001 | 0.84 (0.59 to 1.20); 0.3408 | 2.65 (1.96 to 3.58); <0.0001 |
| Tibia | 1.77 (1.41 to 2.22); <0.0001 | 0.87 (0.66 to 1.13); 0.2964 | 1.71 (1.30 to 2.24); 0.0001 |
| Patella | 1.40 (1.12 to 1.75); 0.0030 | 1.27 (0.97 to 1.64); 0.0777 | 1.30 (1.01 to 1.68); 0.0457 |
ORs (95% CI) and p values for being a progressor knee for a 1 SD greater increase in bone biomarkers, adjusted for baseline joint space width, baseline Western Ontario and McMaster Universities Arthritis Index pain, baseline age, baseline body mass index, baseline Kellgren and Lawrence grade (KLG), baseline pain medication use, sex and race.