LLDAS definition
| Domain and items | Mean agreement score* in Delphi Round 2 |
|---|---|
| Disease activity | |
| 1. SLEDAI-2K ≤4, with no activity in major organ systems (renal, CNS, cardiopulmonary, vasculitis, fever) and no haemolytic anaemia or gastrointestinal activity | 5.0 |
| 2. No new features of lupus disease activity compared with the previous assessment | 4.7 |
| 3. SELENA-SLEDAI physician global assessment (PGA, scale 0–3) ≤1 | 4.8 |
| Immunosuppressive medications | |
| 4. Current prednisolone (or equivalent) dose ≤7.5 mg daily | 4.5 |
| 5. Well tolerated standard maintenance doses of immunosuppressive drugs and approved biological agents, excluding investigational drugs | 4.5 |
*Scale 1 to 5, where 1=strongly disagree, 2=disagree, 3=unsure, 4=agree, 5=strongly agree.
CNS, central nervous system; LLDAS, Lupus Low Disease Activity State; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index.