TableĀ 1

Genetic variants significantly associated with antibody-associated vasculitis (AAV) after meta-analysis

Variant by gene (minor allele)Publications (n)Cases (n)/controls (n)OR (95% CI)p Value for meta-analysisI2 (%)p Value for heterogeneityp Value for funnel plot asymmetry*
CD226 rs763361 (T)32422/178981.14 (1.07 to 1.21)<0.00100.4440.792
CTLA-4 (AT)864303/5430.54 (0.43 to 0.67)<0.00189<0.0010.946
CTLA-4 rs231775 (G)31002/61791.16 (1.06 to 1.28)0.002600.0800.080
CTLA-4 rs3087243 (A)32015/78550.81 (0.75 to 0.87)<0.001250.2620.122
FCGR2A rs1801274 (C)61239/62090.90 (0.82 to 0.99)0.02800.8340.788
HLA-B52335/65730.59 (0.38 to 0.92)0.01900.432N/A
HLA-B86475/78551.48 (1.04 to 2.11)0.028470.0960.063
HLA-DPA1 rs9277341 (C)21032/22000.35 (0.30 to 0.40)<0.001540.1160.215
HLA-DPB1*030151154/13370.38 (0.21 to 0.69)0.00278<0.0010.938
HLA-DPB1*040151154/13371.99 (1.44 to 2.74)<0.00184<0.0010.738
HLA-DPB2 rs3130215 (A)31417/72491.40 (1.29 to 1.52)<0.00199<0.0010.446
HLA-DQB1*03033176/2181.82 (1.09 to 3.03)0.021170.3010.916
HLA-DR65487/62220.50 (0.27 to 0.95)0.033550.0620.997
HLA-DRB1*11012268/4651.89 (1.15 to 3.08)0.01100.487N/A
HLA-DRB1*12012216/4650.37 (0.15 to 0.91)0.03100.491N/A
HLA-DRB1*134233/8330.47 (0.32 to 0.70)<0.00100.5040.884
HLA-DRB1*144322/8621.91 (1.07 to 3.42)0.02900.7280.700
HLA-DRB1*153236/6331.86 (1.39 to 2.50)<0.001690.0210.347
HLA-DRB1*15012216/4651.68 (1.20 to 2.34)0.00200.925N/A
HLA-DRB34260/18450.62 (0.49 to 0.79)<0.001680.0240.689
HLA-DRB44260/18451.69 (1.36 to 2.10)<0.001610.0550.533
HSD17B8 rs421446 (C)2738/18720.40 (0.34 to 0.48)<0.00100.620N/A
IRF5 rs10954213 (G)31535/69770.77 (0.70 to 0.83)<0.00199<0.0010.948
PTPN22 rs2476601 (A)42099/86781.39 (1.24 to 1.56)<0.00100.6930.500
RING1/RXRB rs213213 (A)31414/72381.71 (1.57 to 1.86)<0.001730.0260.187
RXRB rs6531 (C)31557/69551.63 (1.50 to 1.77)<0.00196<0.0010.292
RXRB rs9277935 (T)31417/72330.44 (0.37 to 0.50)<0.001730.0250.393
SERPINA1 S allele51474/57621.30 (1.03 to 1.63)0.02500.4640.547
SERPINA1 Z allele83662/85812.94 (2.22 to 3.88)<0.001410.0920.078
STAT4 rs7574865 (T)31520/69561.11 (1.01 to 1.22)0.02930.3570.590
TLR9 rs352162 (T)11289/18981.58 (1.43 to 1.75)<0.00196<0.001N/A
TLR9 rs352140 (T)11289/18981.13 (1.02 to 1.25)0.01800.432N/A
TLR9 rs352139 (T)11289/18981.11 (1.00 to 1.23)0.04100.756N/A
  • *Harbord test for funnel plot asymmetry was performed for all genetic variants, except for CD226 rs763361, CTLA-4 rs3087243, and PTPN22 rs2476601. In these cases, the Harbord test was not applicable and the Egger test was performed.