| Achievement of LDA | Year category | P value for trend | |||
|---|---|---|---|---|---|
| 2002–2004 | 2005–2007 | 2008–2010 | 2011–2013 | ||
| 1st Biologic | N=282 | N=615 | N=684 | N=1188 | |
| Unadjusted (%) | 43 | 53 | 58 | 51 | 0.0003 |
| Adjusted* OR (95% CI) | 0.68 | 0.93 | 1.21 | 1 | |
| (0.51–0.90) | (0.75–1.15) | (0.99–1.49) | |||
| 2nd Biologic | N=127 | N=419 | N=657 | N=978 | |
| Unadjusted (%) | 40 | 38 | 42 | 42 | 0.55 |
| Adjusted* OR (95% CI) | 0.85 | 0.84 | 1.00 | 1 | |
| (0.50–1.43) | (0.65–1.09) | (0.81–1.25) | |||
| ≥3rd Biologic | N=55 | N=170 | N=460 | N=899 | |
| Unadjusted (%) | 20 | 32 | 37 | 35 | 0.09 |
| Adjusted* OR (95% CI) | 0.44 | 0.95 | 1.13 | 1 | |
| (0.22–0.89) | (0.66–1.37) | (0.88–1.44) | |||
*Adjusted for age, gender, body mass index, disease duration, baseline CDAI, patient pain, functional status and insurance.