Key structural differences*IC Manufacturer
Shanghai CP GuojianLafrancolCiplaProbiomedAryoGen
Identity (tryptic peptide map HPLC): AtypicalY
Aggregation (SE HPLC): above specification limitYYY
Charged species (IEF/AEX chromatography): Differences in distribution vs ETNYYYY
Purity (HIC): Atypical profileYYY
Carbohydrate profile (N-linked oligosaccharide map): Atypical (additional species not in ETN profile)YY
  • *Relative to ETN release specifications and additional characterization historical data. Y, yes.