Inverse variance meta-analysis of four TYK2 SNPs in seven different cohorts of patients with SSc and healthy controls (7103 patients with SSc and 12 220 controls)
| Inverse variance test | ||||||||
|---|---|---|---|---|---|---|---|---|
| Chr | SNP | Minor/major | Comment | MAF cases | MAF controls | p Value | OR (95% CI)* | Q |
| 19 | rs34536443 (P1104A) | C/G | missense Pro >Ala | 0.023 | 0.026 | 2.28E-03 | 0.80 (0.69 to 0.92) | 0.13 |
| 19 | rs35018800 (A928V) | A/G | missense Ala >Val | 0.004 | 0.008 | 1.27E-03 | 0.59 (0.42 to 0.81) | 0.34 |
| 19 | rs12720356 (I684S) | C/A | missense Ile >Ser | 0.067 | 0.078 | 2.63E-05 | 0.83 (0.78 to 0.91) | 0.27 |
| 19 | rs2304256 (V362F) | A/C | missense Val >Phe | 0.246 | 0.279 | 3.08E-13 | 0.83 (0.79 to 0.87) | 0.69 |
*OR for the minor allele.
Chr, chromosome; MAF, minor allele frequency; Q, heterogeneity value; SNP, single-nucleotide polymorphism; SSc, systemic sclerosis.