Predictors of mortality within the cohort of patients with ankylosing spondylitis (AS)
| Baseline frequencies (%) | HR* | 95% CI | |
|---|---|---|---|
| Higher education (>12 years vs ≤12 years) | 2648 (30.8) | 0.67 | 0.53 to 0.85 |
| Longer duration (diagnosis made before 1 January 2006 vs after 1 January 2006) | 5493 (63.9) | 1.03 | 0.84 to 1.36 |
| General comorbidities† | |||
| Cardiovascular disease‡ | 2954 (34.4) | 1.99 | 1.58 to 2.49 |
| Diabetes‡ | 418 (4.9) | 1.92 | 1.51 to 2.45 |
| Chronic pulmonary disease§ | 164 (1.9) | 3.03 | 2.27 to 4.05 |
| Malignancy§ | 427 (5.0) | 1.67 | 1.32 to 2.12 |
| Infections§ | 2829 (32.9) | 2.01 | 1.68 to 2.34 |
| AS-related clinical manifestations† | |||
| Aortic valve insufficiency§ | 79 (0.9) | 1.19 | 0.68 to 2.06 |
| Inflammatory bowel disease§ | 644 (7.5) | 1.23 | 0.92 to 1.65 |
| Anterior uveitis§ | 1731 (20.1) | 0.89 | 0.69 to 1.13 |
| Psoriasis§ | 512 (6.0) | 1.13 | 0.81 to 1.57 |
| Peripheral arthritis§ | 1841 (21.4) | 1.17 | 0.95 to 1.44 |
| Joint surgery† | |||
| Hip replacement surgery§ | 432 (5.0) | 1.65 | 1.29 to 2.12 |
| Other joint surgery (small or large joints)§ | 213 (2.5) | 0.78 | 0.48 to 1.24 |
*Age-adjusted and sex-stratified analysis.
†Registered before the start of follow-up.
‡Based on either a visit to physician with such diagnosis (according to International Classification of Disease (ICD) codes—data from the National Patient Register (NPR)) or on dispensing of pharmacological agents suggesting such diagnosis (according to Anatomical Therapeutic Chemical (ATC) codes—data from the Prescribed Drugs Register).
§Based on a visit to physician with such diagnoses (according to ICD-codes—data from the NPR).