Table 2

Improvement in disease activity states at 3 months

MDA (baseline)
→ LDA (3 months)
MDA (baseline)
→REM (3 months)
HDA (baseline)
→ MDA (3 months)
HDA (baseline)
→ LDA (3 months)
HDA (baseline)
→ REM (3 months)
Simplified Disease Activity Index (SDAI)N=1654*9538933444144
Relative change, 3 months65.2 (13.1)90.5 (4.2)57.1 (13.9)81.1 (7.2)95.3 (2.5)
Absolute change, 3 months13.9 (4.1)19.5 (3.3)26.4 (11.8)33.4 (11.4)39.7(10.5)
% with LDA (incl. REM), 6 months77.9% (n=74)89.5% (n=34)36% (n=336)76.4% (n=339)93.8% (n=135)
% with REM, 6 months22.1% (n=21)60.5% (n=23)4.5% (n=42)21.4% (n=95)63.9% (n=92)
Clinical Disease Activity Index (CDAI)N=1534*5925820480150
Relative change, 3 months64.9 (13.4)90.8 (4.2)58.2 (13.6)81.2 (7.9)96.2 (2.7)
Absolute change, 3 months11.6 (3.5)16.6 (2.0)24.3 (11.2)30.5 (11.0)35.9 (10.4)
% with LDA (incl. REM), 6 months78% (n=46)88% (n=22)37.2% (n=305)75.6% (n=363)94% (n=141)
% with REM, 6 months22% (n=13)60% (n=15)5.2% (n=43)22.5% (n=108)66.7% (n=100)
Disease Activity Score 28-CRP (DAS28-CRP)N=1740*961331035223253
Relative change, 3 months35.6 (7.6)54.6 (9.5)32.6 (10.3)51.8 (5.9)65.8 (7.5)
Absolute change, 3 months1.6 (0.5)2.5 (0.6)2.1 (0.8)3.2 (0.7)4.0 (0.8)
% with LDA (incl. REM), 6 months75% (n=72)90.2% (n=120)31.4% (n=325)61.4% (n=137)85% (n=215)
% with REM, 6 months46.9% (n=45)72.9% (n=97)13.3% (n=138)34.5% (n=77)68.4% (n=173)
Disease Activity Score 28-ESR (DAS28-ESR)N=796*263152299118
Relative change, 3 months31.2 (9.8)54.2 (9.4)35.9 (10.7)53.9 (6.1)68.1 (8.1)
Absolute change, 3 months1.4 (0.6)2.4 (0.5)2.5 (0.9)3.5 (0.8)4.4 (1.0)
% with LDA (incl. REM), 6 months57.7% (n=15)87.1% (n=27)27.4% (n=143)68.7% (n=68)86.4% (n=102)
% with REM, 6 months34.6% (n=9)71% (n=22)13.8% (n=72)41.4% (n=41)66.7% (n=92)
  • Associated absolute and relative changes in the scores, and implications regarding achievement of the target at 6 months.

  • *The following patients were excluded: patients in LDA or REM already at baseline by the respective score; patients staying in the same state at baseline and 3 months; patients worsening their state from baseline to 3 months. DAS28-ESR numbers are smaller due to the lack of ESR measurement in some of the studies.

  • CRP, C reactive protein; ESR, erythrocyte sedimentation rate; HDA, high disease activity; LDA, low disease activity; MDA, moderate disease activity; REM, remission.