Table 3

Risk of incident atrial fibrillation* in patients with gout compared with those with osteoarthritis

AdjustmentHR (95% CI)
Main analysis
Age, sex1.23 (1.14 to 1.32)
+Comorbidity score and number of prescription drugs1.19 (1.11 to 1.28)
Final model†1.13 (1.04 to 1.23)
Stratified analysis
By obesity
 Yes1.26 (1.02 to 1.56)
 No1.18 (1.09 to 1.27)
By diabetes
 Yes1.11 (0.96 to 1.27)
 No1.21 (1.11 to 1.31)
By history of CVD
 Yes1.25 (1.01 to 1.41)
 No1.15 (1.05 to 1.26)
Subgroup analysis
Patients with baseline ESR/CRP levels available (n=15 174)
 Age, sex1.17 (0.78 to 1.76)
 +Comorbidity score and number of prescription drugs1.12 (0.74 to 1.69)
 +High ESR/CRP1.06 (0.70 to 1.61)
Patients with baseline uric acid levels available (n=20 622)
 Age, sex1.32 (0.88 to 1.97)
 +Comorbidity score and number of prescription drugs1.33 (0.89 to 2.00)
 +Serum uric acid level1.19 (0.78 to 1.83)
  • *Defined with an inpatient or outpatient diagnosis of AF and a dispensing of anticoagulants/antiarrhythmics.

  • †The final model includes age, sex, comorbidities, medications and healthcare usage factors listed in table 1.

  • ‡Stratified analyses were adjusted for age, sex, comorbidity score and number of prescription drugs.

  • AF, atrial fibrillation; CRP, C reactive protein; CVD, cardiovascular disease; ESR, erythrocyte sedimentation rate.