Stepwise logistic regression model of risk factors for hyperuricaemia (SU≥0.42 mmol/L)
| Significant variables | OR (95% CI) | p Value |
|---|---|---|
| ABCG2 Q141K genotype | ||
| Wild type | 1 | |
| Heterozygous | 2.71 (1.60 to 4.60) | 2.3×10−4 |
| Homozygous | 10.15 (2.37 to 43.43) | 1.8×10−3 |
| FCU (%)* | 1.50 (1.37 to 1.65) | 1.0×10−17 |
| Sex | ||
| Male | 11.06 (6.32 to 19.34) | 3.8×10−17 |
| BMI (kg/m2) | 1.17 (1.12 to 1.22) | 4.6×10−14 |
| TG (0.1 mmol/L) | 1.02 (1.01 to 1.04) | 5.6×10−3 |
| eGFR (10 mL/min/1.73 m2)† | 1.69 (1.50 to 1.90) | 4.0×10−20 |
| Alcohol (10 g/week‡) | 1.03 (1.01 to 1.06) | 9.1×10−3 |
*For each 1% decrease in FCU, there was a 50% increase in the OR for hyperuricaemia.
†For each 10 mL/min/1.73 m2 decrease in eGFR, there was a 69% increase in the OR for hyperuricaemia.
‡10 g of alcohol—‘standard drink’ size in Australia and New Zealand.
ABCG2, ATP-binding cassette transporter, sub-family G 2; BMI, body mass index; eGFR, estimated glomerular filtration rate; FCU, fractional clearance of urate; SU, serum urate; TG, triglyceride.