Outcome | 0–2 years | 2–5 years | 5+ years | Overall |
---|---|---|---|---|
CIN 1 | ||||
HR* | 1.77 (1.14 to 2.73) | 1.05 (0.61 to 1.79) | 0.74 (0.37 to 1.49) | 1.23 (0.87 to 1.74) |
N events, TNFi | 27 | 16 | 9 | 52 |
N patients, TNFi | 8943 | 7418 | 5007 | 8943 |
Pyr, TNFi | 16 474 | 18 609 | 19 499 | 54 581 |
CIN 2+ | ||||
HR* | 1.55 (1.04 to 2.32) | 1.39 (0.92 to 2.10) | 1.06 (0.63 to 1.78) | 1.36 (1.01 to 1.82) |
N events, TNFi | 30 | 28 | 17 | 75 |
N patients, TNFi | 9018 | 7493 | 5066 | 9018 |
Pyr, TNFi | 16 629 | 18 808 | 19 707 | 55 144 |
Invasive cervical cancer | ||||
HR* | † | † | 3.22 (1.37 to 7.58) | 2.10 (1.04 to 4.23) |
N events, TNFi | 4 | 2 | 8 | 14 |
N patients, TNFi | 9629 | 8021 | 5449 | 9629 |
Pyr, TNFi | 17 774 | 20 166 | 21 251 | 59 191 |
Stratified by time since start of follow-up (<2 years, 2–5 years, 5+ years).
*Stratified on decade of birth and adjusted for educational level, number of cervical screens past five years, comorbidities, marital status and total days spent in hospital during last five years, also implicitly adjusted for age since age was used as the model's timescale.
†Not computed due to low number of events.
CIN, cervical intraepithelial neoplasia.