Table 1

Validation constructs: discrimination between low disease activity and high disease activity according to physician's global assessment at baseline

 ABILITY-2TIPES
Low (<40) mean (SD)
n=15
High (≥60) mean (SD)
n=84
SMDLow (<40) mean (SD)
n=6
High (≥60) mean (SD)
n=12
SMD
PGA, 0–100 mm VAS55.3 (17.0)71.0 (15.7)0.9945.8 (13.4)75.2 (15.1)2.01
Patient global pain, 0–100 mm VAS53.7 (14.8)69.7 (15.5)1.0334.4 (21.0)58.2 (18.5)−0.04
ASDAS-CRP, 0–10 cm VAS2.3 (0.8)3.2 (0.8)1.161.9 (0.7)3.4 (0.9)1.84
BASDAI total (0–10 cm VAS)4.2 (1.9)6.0 (1.5)1.133.4 (1.5)6.2 (1.7)1.75
 BASDAI #14.4 (1.9)6.6 (2.1)0.892.8 (1.1)7.2 (1.9)2.66
 BASDAI #22.7 (2.7)4.3 (3.0)0.533.4 (2.6)5.9 (3.5)0.77
 BASDAI #35.4 (2.2)7.1 (1.6)1.003.9 (2.6)6.2 (2.6)0.87
 BASDAI #44.3 (2.8)6.5 (2.1)0.973.0 (2.3)5.5 (2.8)0.94
 BASDAI #54.9(2.9)6.1 (2.4)0.504.9 (2.5)7.1 (2.2)1.00
 BASDAI #63.4 (2.8)5.6 (2.8)0.782.6 (1.9)5.2 (3.5)0.83
 BASDAI mean #5 and #64.1 (2.7)5.8 (2.3)0.713.7 (2.1)6.2 (2.7)1.00
SJC76*5.1 (5.1)7.5 (8.1)0.312.5 (2.7)4.2 (3.4)0.52
TJC78†8.3 (4.9)14.8 (15.7)0.455.7 (3.8)9.0 (6.5)0.57
CRP (mg/L)7.3 (8.9)13.0 (20.7)0.291.6 (1.1)16.7 (31.0)0.59
  • *In TIPES, SJC was 0–66 joints.

  • †TJC 0-68 joints and patient global pain were derived from the mean of BASDAI #3 and #4.

  • ASDAS-CRP, Ankylosing Spondylitis Disease Activity Score based on C-reactive protein; BASDAI, Bath Ankylosing Spondylitis Disease Activity Index; CRP, C-reactive protein; PGA, patient global assessment; SJC, swollen joint count; SMD, standardised mean difference; TIPES, Tnf Inhibition in PEripheral SpondyloArthritis; TJC, tender joint count; VAS, visual analogue scale.