ABILITY-2 | TIPES | |||||
---|---|---|---|---|---|---|
Low (<40) mean (SD) n=15 | High (≥60) mean (SD) n=84 | SMD | Low (<40) mean (SD) n=6 | High (≥60) mean (SD) n=12 | SMD | |
PGA, 0–100 mm VAS | 55.3 (17.0) | 71.0 (15.7) | 0.99 | 45.8 (13.4) | 75.2 (15.1) | 2.01 |
Patient global pain, 0–100 mm VAS | 53.7 (14.8) | 69.7 (15.5) | 1.03 | 34.4 (21.0) | 58.2 (18.5) | −0.04 |
ASDAS-CRP, 0–10 cm VAS | 2.3 (0.8) | 3.2 (0.8) | 1.16 | 1.9 (0.7) | 3.4 (0.9) | 1.84 |
BASDAI total (0–10 cm VAS) | 4.2 (1.9) | 6.0 (1.5) | 1.13 | 3.4 (1.5) | 6.2 (1.7) | 1.75 |
BASDAI #1 | 4.4 (1.9) | 6.6 (2.1) | 0.89 | 2.8 (1.1) | 7.2 (1.9) | 2.66 |
BASDAI #2 | 2.7 (2.7) | 4.3 (3.0) | 0.53 | 3.4 (2.6) | 5.9 (3.5) | 0.77 |
BASDAI #3 | 5.4 (2.2) | 7.1 (1.6) | 1.00 | 3.9 (2.6) | 6.2 (2.6) | 0.87 |
BASDAI #4 | 4.3 (2.8) | 6.5 (2.1) | 0.97 | 3.0 (2.3) | 5.5 (2.8) | 0.94 |
BASDAI #5 | 4.9(2.9) | 6.1 (2.4) | 0.50 | 4.9 (2.5) | 7.1 (2.2) | 1.00 |
BASDAI #6 | 3.4 (2.8) | 5.6 (2.8) | 0.78 | 2.6 (1.9) | 5.2 (3.5) | 0.83 |
BASDAI mean #5 and #6 | 4.1 (2.7) | 5.8 (2.3) | 0.71 | 3.7 (2.1) | 6.2 (2.7) | 1.00 |
SJC76* | 5.1 (5.1) | 7.5 (8.1) | 0.31 | 2.5 (2.7) | 4.2 (3.4) | 0.52 |
TJC78† | 8.3 (4.9) | 14.8 (15.7) | 0.45 | 5.7 (3.8) | 9.0 (6.5) | 0.57 |
CRP (mg/L) | 7.3 (8.9) | 13.0 (20.7) | 0.29 | 1.6 (1.1) | 16.7 (31.0) | 0.59 |
*In TIPES, SJC was 0–66 joints.
†TJC 0-68 joints and patient global pain were derived from the mean of BASDAI #3 and #4.
ASDAS-CRP, Ankylosing Spondylitis Disease Activity Score based on C-reactive protein; BASDAI, Bath Ankylosing Spondylitis Disease Activity Index; CRP, C-reactive protein; PGA, patient global assessment; SJC, swollen joint count; SMD, standardised mean difference; TIPES, Tnf Inhibition in PEripheral SpondyloArthritis; TJC, tender joint count; VAS, visual analogue scale.