Variable | Fluorinated steroids (N=71) | No fluorinated steroids (N=85) | p Value |
---|---|---|---|
Maternal age at time of birth, years (Mean±SD) | 30.1±4.3 | 30.3±4.6 | 0.79 |
Cardiac-NL heart block | |||
Third degree | 62 (87.3%) | 81 (95.3%) | 0.09 |
Second degree | 9 (12.7%) | 4 (4.7%) | |
Race/ethnicity* | 0.57 | ||
White | 54 (76.1%) | 68 (80.0%) | |
Black | 7 (9.9%) | 4 (4.7%) | |
Hispanic | 6 (8.5%) | 8 (9.4%) | |
Asian | 2 (2.8%) | 2 (2.4%) | |
Other/NA | 2 (2.8%) | 3 (3.5%) | |
Maternal diagnosis† | 0.63 | ||
Asym/UAS | 39 (54.9%) | 50 (58.8%) | |
SS | 18 (25.4%) | 18 (21.2%) | |
SLE | 7 (9.9%) | 12 (14.1%) | |
SLE/SS | 7 (9.9%) | 5 (5.9%) | |
Antibody status | |||
Maternal anti-SSA Ro 60 kD | 71 (100%) | 85 (100%) | |
Maternal anti-SSB/La 48 kD (N=154) | 47 (68.1%) | 50 (58.8%) | 0.25 |
Maternal anti-Ro 52 kD (N=128) | 49 (89.1%) | 71 (97.3%) | 0.07 |
Sex of child (N=155) | |||
Male | 36 (48.6%) | 37 (43.5%) | 0.34 |
Female | 34 (51.4%) | 48 (56.5%) | |
Average date of birth | 7/2002 | 4/1998 | 0.0004 |
Medications | |||
Sympathomimetics | 11 (15.5%) | 11 (12.9%) | 0.65 |
Non-fluorinated steroids | 10 (14.1%) | 13 (15.3%) | 1.0 |
IVIG | 2 (2.8%) | 2 (2.4%) | 1.0 |
Plasmapheresis | 1 (1.4%) | 0 (0.0%) | 0.46 |
Hydroxychloroquine | 9 (12.0%) | 1 (1.2%) | 0.006 |
Azathioprine | 0 (0%) | 1 (1.2%) | 1.0 |
Gestational age at detection (weeks) | 22.1±2.8 | 22.8±3.1 | 0.13 |
Ventricular rate at detection BPM (N=124) | 69.0±21.8 | 64.4±12.5 | 0.15 |
Ventricular rate at nadir BPM (N=143) | 54.2±11.9 | 53.1±12.1 | 0.56 |
Gestational age at delivery (weeks) | 36.4±2.3 | 36.6±2.8 | 0.67 |
Preterm delivery (<37 weeks)‡ | 29 (42.6%) | 31 (38.3%) | 0.62 |
Delivery via C-section (n=144)‡ | 59 (87.7%) | 65 (82.3%) | 0.48 |
Age, gestational age of detection and delivery and ventricular rate at detection and delivery are presented as mean with SD. All other data are reported as N (%).
*p Value represents the comparison between white and all other races/ethnicities.
†p Value represents comparison of Asym/UAS and all other diagnoses.
‡Did not include seven in utero deaths.
Asym, asymptomatic; BPM, beats per minute; C-section, caesarean section; IVIG, intravenous immunoglobulin; NA, not available; NL, neonatal lupus; SLE, systemic lupus erythematosus; SS, Sjogren's syndrome; UAS, undifferentiated autoimmune syndrome.