Table 1

Clinical and demographic characteristics

VariableFluorinated steroids (N=71)No fluorinated steroids (N=85)p Value
Maternal age at time of birth, years (Mean±SD)30.1±4.330.3±4.60.79
Cardiac-NL heart block
 Third degree62 (87.3%)81 (95.3%)0.09
 Second degree9 (12.7%)4 (4.7%)
Race/ethnicity*0.57
 White54 (76.1%)68 (80.0%)
 Black7 (9.9%)4 (4.7%)
 Hispanic6 (8.5%)8 (9.4%)
 Asian2 (2.8%)2 (2.4%)
 Other/NA2 (2.8%)3 (3.5%)
Maternal diagnosis†0.63
 Asym/UAS39 (54.9%)50 (58.8%)
 SS18 (25.4%)18 (21.2%)
 SLE7 (9.9%)12 (14.1%)
 SLE/SS7 (9.9%)5 (5.9%)
Antibody status
 Maternal anti-SSA Ro 60 kD71 (100%)85 (100%)
 Maternal anti-SSB/La 48 kD (N=154)47 (68.1%)50 (58.8%)0.25
 Maternal anti-Ro 52 kD (N=128)49 (89.1%)71 (97.3%)0.07
Sex of child (N=155)
 Male36 (48.6%)37 (43.5%)0.34
 Female34 (51.4%)48 (56.5%)
Average date of birth7/20024/19980.0004
Medications
 Sympathomimetics11 (15.5%)11 (12.9%)0.65
 Non-fluorinated steroids10 (14.1%)13 (15.3%)1.0
 IVIG2 (2.8%)2 (2.4%)1.0
 Plasmapheresis1 (1.4%)0 (0.0%)0.46
 Hydroxychloroquine9 (12.0%)1 (1.2%)0.006
 Azathioprine0 (0%)1 (1.2%)1.0
Gestational age at detection (weeks)22.1±2.822.8±3.10.13
Ventricular rate at detection BPM (N=124)69.0±21.864.4±12.50.15
Ventricular rate at nadir BPM (N=143)54.2±11.953.1±12.10.56
Gestational age at delivery (weeks)36.4±2.336.6±2.80.67
Preterm delivery (<37 weeks)‡29 (42.6%)31 (38.3%)0.62
Delivery via C-section (n=144)‡59 (87.7%)65 (82.3%)0.48
  • Age, gestational age of detection and delivery and ventricular rate at detection and delivery are presented as mean with SD. All other data are reported as N (%).

  • *p Value represents the comparison between white and all other races/ethnicities.

  • †p Value represents comparison of Asym/UAS and all other diagnoses.

  • ‡Did not include seven in utero deaths.

  • Asym, asymptomatic; BPM, beats per minute; C-section, caesarean section; IVIG, intravenous immunoglobulin; NA, not available; NL, neonatal lupus; SLE, systemic lupus erythematosus; SS, Sjogren's syndrome; UAS, undifferentiated autoimmune syndrome.