Table 2

Cumulative probabilities of flare within 3, 6 and 12 months after stopping all antirheumatic treatments

PatientsProbability of flare after stopping treatment (95% CI)
N*Within 3 monthsWithin 6 monthsWithin 12 months
Any flareSignificant flareAny flareSignificant flareAny flareSignificant flare
Whole cohort6250.060 (0.043 to 0.084)0.053 (0.037 to 0.075)0.172 (0.142 to 0.207)0.137 (0.110 to 0.170)0.317 (0.278 to 0.360)0.250 (0.214 to 0.290)
Systemic arthritis370.030 (0.004 to 0.196)0.030 (0.004 to 0.196)0.062 (0.016 to 0.225)0.030 (0.004 to 0.196)0.062 (0.016 to 0.225)0.030 (0.004 to 0.196)
Oligoarthritis persistent3100.058 (0.036 to 0.092)0.054 (0.033 to 0.088)0.156 (0.118 to 0.205)0.127 (0.093 to 0.173)0.330 (0.277 to 0.391)0.259 (0.210 to 0.316)
Oligoarthritis extended†8
RF-negative polyarthritis850.071 (0.030 to 0.163)0.057 (0.022 to 0.145)0.217 (0.137 to 0.334)0.188 (0.114 to 0.302)0.402 (0.293 to 0.534)0.355 (0.251 to 0.486)
RF-positive polyarthritis†4
Psoriatic arthritis440.057 (0.015 to 0.210)0.057 (0.015 to 0.210)0.143 (0.062 to 0.310)0.114 (0.044 to 0.276)0.172 (0.081 to 0.344)0.144 (0.062 to 0.312)
ERA770.083 (0.035 to 0.188)0.066 (0.025 to 0.167)0.242 (0.151 to 0.374)0.190 (0.110 to 0.317)0.389 (0.275 to 0.529)0.302 (0.199 to 0.441)
Undifferentiated arthritis600.065 (0.021 to 0.189)0.043 (0.011 to 0.160)0.219 (0.124 to 0.369)0.153 (0.076 to 0.294)0.331 (0.214 to 0.488)0.222 (0.126 to 0.373)
  • *Number of subjects who discontinued treatment.

  • †The probability of flares after stopping treatment is not reported because few subjects stopped treatment in this JIA category.

  • ERA, enthesitis-related arthritis; JIA, juvenile idiopathic arthritis; RF, rheumatoid factor.