Table 3

Treatment failure by reason, unadjusted (%)

Subcutaneous methotrexateOral methotrexatep Value (χ2)
Total treatment failures4977<0.001
Inefficacy only2859<0.001
Toxicity* only320.63
Both inefficacy and toxicity*18160.57
  • *Toxicity was defined as physician documented side effects resulting in change in therapy.