Table 2

Adjusted association between route of initial methotrexate and outcomes

OutcomeEstimate for subcutaneous methotrexate (95% CI)p Value
Treatment failure, HR0.55 (0.39 to 0.79)0.001
DAS-28, mean difference−0.38 (−0.64 to −0.10)0.04
DAS-28 remission, OR1.15 (1.05 to 1.25)0.002
DAS-28 sustained remission*, OR1.02 (0.96 to 1.06)0.43
HAQ-DI, mean difference−0.02 (−0.13 to 0.10)0.75
  • *Defined as DAS-28 <2.6 on two consecutive visits.

  • DAS-28, Disease Activity Score-28; HAQ-DI, Health Assessment Questionnaire-Disability Index.