Gene locus | pSS associated SNP* | Top CpG site | metQTL p Value | pSS EWAS p Value |
---|---|---|---|---|
DDX6-CXCR5 | rs4936443 | cg09144398 | 2.5×10−3 | 9.9×10−4 |
FAM167A-BLK | rs2736345 | cg21775007 | 2.1×10−9 | 0.02 |
IL12A | rs485497 | cg25829945 | 0.02 | 0.03 |
IL12A | rs583911 | cg07906551 | 0.01 | 4.5×10−8 |
IRF5-TNPO3 | rs4728142 | cg04864179 | 4.8×10−9 | 4.8×10−13 |
IRF5-TNPO3 | rs17339836 | cg04864179 | 4.6×10−4 | 4.8×10−13 |
IRF5-TNPO3 | rs10954213 | cg04864179 | 6.9×10−6 | 4.8×10−13 |
STAT4 | rs13426947 | cg15325732 | 0.01 | 0.03 |
TNIP1 | rs6579837 | cg19084508 | 0.03 | 2.5×10−3 |
TNIP1 | rs7732451 | cg15989436 | 0.04 | 1.5×10−13 |
HLA-DRA | rs3135394 | cg25645491 | 8.2×10−13 | 2.0×10−3 |
HLA-DQB1 | rs115575857 | cg07180897 | 3.0×10−70 | 8.9×10−7 |
HLA-DQB1 | rs3129716 | cg07180897 | 3.0×10−70 | 8.9×10−7 |
HLA-DQA1 | rs9271588 | cg08269402 | 4.1×10−51 | 5.0×10−4 |
*Single nucleotide polymorphism (SNP) associated with pSS at genome-wide significance reported by Lessard et al.9
EWAS, epigenome-wide association study.