Table 2

HRs for myocardial infarction associated with factors controlled in the multivariate Cox models*

HR95% CI
Male1.390.98 to 1.99
Socioeconomic status (SES)0.970.95 to 0.99
Seropositive (referent to seronegative)1.231.03 to 1.48
Missing serology (referent to seronegative)1.301.05 to 1.59
Current smoker (referent to never smoker)1.421.14 to 1.77
Former smoker (referent to never smoker)1.080.89 to 1.31
Missing smoking data (referent to never smoker)1.721.26 to 2.34
Steroids 1–7.5 mg/day (ref to no use)†1.321.13 to 1.54
Steroids >7.5 mg/day (ref to no use)†1.751.42 to 2.15
Statin1.431.24 to 1.65
Methotrexate (MTX)+DMARD (ref to non-biological DMARD other than MTX)0.830.65 to 1.00
Biologics‡ (ref to non-biological DMARD other than MTX)0.820.65 to 1.05
No RA medication (no biological, no DMARD; ref to non-biological DMARD other than MTX)0.870.72 to 1.06
Chronic obstructive pulmonary disease1.541.27 to 1.86
Chronic kidney disease2.301.60 to 3.32
Diabetes mellitus1.761.48 to 2.09
Heart failure1.711.28 to 2.28
Hypertension1.060.92 to 1.23
  • Note: These are the covariates controlled for in the adjusted Cox models (HRs) models depicted in figure 2.

  • *Models also controlled for body mass index, but not statistically significant. Comorbidities determined and controlled for at baseline.

  • Steroid dose calculated as the mean daily dose during the 6 months prior to the index date.

  • Biological included all antitumor necrosis factor biologics, rituximab and abatacept with or without non-biological DMARD.

  • DMARD, disease-modifying antirheumatic drug; RA, rheumatoid arthritis.