Domain | Quadriceps | Biceps | ||
---|---|---|---|---|
ICC | α Score | ICC | α Score | |
Inflammatory domain | 0.81 (0.61 to 0.93) | 0.38 (0.19 to 0.74) | 0.80 (0.62 to 0.93) | 0.34 (0.16 to 0.68) |
CD3+ endomysial infiltration | 0.72 (0.53 to 0.89) | 0.15 (0.0 to 0.39) | 0.74 (0.56 to 0.90) | 0.26 (0.08 to 0.54) |
CD3+ perimysial infiltration | 0.61 (0.39 to 0.83) | 0.31 (0.05 to 0.67) | 0.75 (0.57 to 0.91) | 0.20 (0 to 0.44) |
CD3+ perivascular infiltration | 0.58 (0.37 to 0.82) | 0.41 (0.14 to 0.84) | 0.58 (0.37 to 0.82) | 0.44 (0.17 to 0.90) |
CD68+ endomysial infiltration | 0.66 (0.45 to 0.86) | 0.40 (0.17 to 0.82) | 0.62 (0.41 to 0.84) | 0.22 (0.0 to 0.53) |
CD68+ perimysial infiltration | 0.48 (0.27 to 0.76) | 0.59 (0.24 to 1.2) | 0.79 (0.63 to 0.93) | 0.18 (0.0 to 0.40) |
CD68+ perivascular infiltration | 0.40 (0.20 to 0.70) | 0.83 (0.37 to 1.65) | 0.33 (0.15 to 0.63) | 0.97 (0.43 to 0.93) |
Vascular domain | 0.48 (0.27 to 0.76) | 0.57 (0.23 to 1.2) | 0.49 (0.28 to 0.76) | 0.54 (0.21 to 1.10) |
Capillary dropout | 0.39 (0.20 to 0.68) | 0.73 (0.29 to 1.47) | 0.26 (0.11 to 0.55) | 0.95 (0.34 to 2.0) |
Arterial abnormality | 0.40 (0.21 to 0.70) | 0.56 (0.18 to 1.18) | 0.42 (0.23 to 0.71) | 0.52 (0.15 to 1.09) |
Infarction | 0 (0 to 0.16) | 0 | 0.42 (0.22 to 0.71) | 0.34 (0 to 0.80) |
Muscle fibre domain | 0.80 (0.63 to 0.93) | 0.25 (0.10 to 0.52) | 0.86 (0.71 to 0.95) | 0.26 (0.12 to 0.52) |
MHC class I overexpression | 0.31 (0.14 to 0.62) | 0.28 (0.0 to 0.82) | 0 (0 to 0.14) | 0 |
Perifascicular atrophy | 0.63 (0.43 to 0.85) | 0.28 (0 to 0.61) | 0.76 (0.58 to 0.910 | 0.29 (0.11 to 0.59) |
Neonatal myosin | 0.83 (0.68 to 0.94) | 0 (0 to 0.20) | 0.88 (0.76 to 0.96) | 0.06 (0 to 0.20) |
Fibre atrophy: non-perifascicular | 0.28 (0.13 to 0.59) | 0.83 (0.29 to 1.72) | 0.32 (0.15 to 0.62) | 0.76 (0.26 to 1.56) |
Regeneration/degeneration/necrosis: perifascicular | 0.58 (0.36 to 0.82) | 0.39 (0.12 to 0.81) | 0.84 (0.70 to 0.94) | 0.18 (0.05 to 0.30) |
Regeneration/degeneration/necrosis: non-perifascicular | 0.51 (0.30 to 0.78) | 0.38 (0.05 to 0.81) | 0.60 (0.38 to 0.83) | 0.50 (0.22 to 1.0) |
Internal myonuclei | 0.63 (0.42 to 0.85) | 0.33 (0.09 to 0.69) | 0.32 (0.15 to 0.63) | 0.63 (0.16 to 1.34) |
Connective tissue domain | 0.34 (0.16 to 0.64) | 0.74 (0.27 to 1.52) | 0.41 (0.21 to 0.70) | 0.62 (0.23 to 1.28) |
Any endomysial fibrosis | 0.35 (0.17 to 0.65) | 0.66 (0.22 to 1.38) | 0.32 (0.15, 0.63) | 0.60 (0.11 to 1.39) |
Any perimysial fibrosis | 0.19 (0.07 to 0.47) | 1.03 (0.26 to 2.17) | 0.36 (0.18 to 0.66) | 0.70 (0.26 to 1.44) |
Histopathologists’ Visual Analogue Score for severity | 0.77 (0.60 to 0.91) | 0.20 (0.03 to 0.44) | 0.87 (0.74 to 0.96) | 0.19 (0.08 to 0.40) |
*All 22 cases used to generate these data were new cases, distinct from the previous study.4
†ICC>0.6 indicates high reliability, α score <0.4 indicates high agreement.
‡Items shown in bold reached good or good*, as detailed in text.