Predictors of inflammatory polyarthritis
| Model 1 (All, n=184/25271) | Model 2 (Women, n=128/13772) | |||||||
|---|---|---|---|---|---|---|---|---|
| Age and gender adjusted | Multivariable* | Age adjusted | Multivariable* | |||||
| Risk factor | HR (95% CI) | p Value | HR (95% CI) | p Value | HR (95% CI) | p Value | HR (95% CI) | Value |
| Pack-years of smoking (every 10 pack-years) | ||||||||
| Men | 1.23 (1.10 to 1.37) | <0.001 | 1.21 (1.08 to 1.37) | 0.002 | ||||
| Women | 1.00 (0.83 to 1.20) | 0.99 | 1.00 (0.82 to 1.21) | 0.98 | 0.99 (0.81 to 1.20) | 0.90 | Not included | |
| Smoking status | ||||||||
| Never smokers | 1 (ref) | Not included | 1 (ref) | 1 (ref) | ||||
| Men, current smokers | 4.81(1.75 to 13.25) | 0.01 | ||||||
| Men, ex-smokers | 2.70 (1.12 to 6.49) | |||||||
| Women, current smokers | 1.49 (0.91 to 2.45) | 0.22 | 1.49 (0.91 to 2.45) | 0.22 | 1.57 (0.95 to 2.60) | 0.14 | ||
| Women, ex-smokers | 0.96 (0.64 to 1.43) | 0.96 (0.64 to 1.43) | 0.93 (0.61 to 1.40) | |||||
| Alcohol (every 7 units/ week) | 0.84 (0.73 to 0.98) | 0.02 | 0.86 (0.74 to 0.99) | 0.04 | 0.76 (0.58 to 0.99) | 0.04 | 0.80 (0.62 to 1.02) | 0.07 |
| BMI | ||||||||
| Normal or underweight (BMI<25) | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) | ||||
| Overweight (BMI 25 to < 30) | 1.11 (0.79 to 1.56) | 1.08 (0.76 to 1.54) | 1.17 (0.77 to 1.76) | 1.06 (0.70 to 1.62) | ||||
| Obese (BMI>30) | 1.52 (1.01 to 2.27) | 0.12 | 1.45 (0.95 to 2.21) | 0.20 | 1.84 (1.17 to 2.91) | 0.03 | 1.61 (1.00 to 2.58) | 0.11 |
| Social class | ||||||||
| Manual worker | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) | ||||
| Technical/skilled/managerial | 0.71 (0.53 to 0.95) | 0.72 (0.53 to 0.99) | 0.63 (0.44 to 0.89) | 0.67 (0.46 to 0.97) | ||||
| Professional | 0.32 (0.13 to 0.80) | 0.01 | 0.36 (0.15 to 0.89) | 0.02 | 0.37 (0.13 to 1.01) | 0.01 | 0.44 (0.16 to 1.22) | 0.05 |
| Education | ||||||||
| No degree | 1 (ref) | Not included | 1 (ref) | Not included | ||||
| Degree | 0.33 (0.16 to 0.68) | 0.002 | 0.06 (0.01 to 0.46) | 0.01 | ||||
| Diabetes mellitus | 3.26 (1.74 to 6.12) | <0.001 | 2.54 (1.26 to 5.09) | 0.01 | 4.55 (2.18 to 9.50) | <0.001 | 4.28 (2.04 to 9.01) | <0.001 |
| Parity | ||||||||
| None | 1 (ref) | 1 (ref) | ||||||
| 1 | 1.30 (0.54 to 3.08) | 1.34 (0.54 to 3.32) | ||||||
| ≥2 | 2.31 (1.18 to 4.52) | 0.01 | 2.81 (1.37 to 5.76) | 0.003 | ||||
| Breast feeding (every 52 weeks) | 0.78 (0.58 to 1.04)† | 0.09 | 0.66 (0.46 to 0.94)† | 0.02 | ||||
*Adjusted for all other variables in model.
†For all women, including nulliparous.
BMI, body mass index.